Brooks Womens Glycerin 22 Neutral Running Shoe - Max Cushioning

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: these are for runners and gym users who want the maximum plush cushioning without added stability devices. The Glycerin 22 centers its appeal on a new DNA Tuned midsole that blends dual-size cells for soft landings and lively toe-offs, and it carries both APMA acceptance and PDAC A5500 diabetic certification, which reinforces its reputation for comfort and an accommodating fit. For anyone prioritizing a luxurious, stable ride on roads or in the gym, this shoe delivers.

Key Features

• Neutral support: Provides a high level of cushioning while maintaining a neutral platform for versatile road running and cross training.
• DNA Tuned cushion: Larger heel cells create plush landings and smaller forefoot cells help produce responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed and breathes well while still offering structure.
• Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot for steady heel-to-toe movement.
• Medical endorsements: Certified PDAC A5500 and APMA Seal of Acceptance indicate suitability for users needing extra foot care consideration.

Who It's For

The Glycerin 22 is ideal for women who want maximum cushioning in a neutral road running shoe and for those who do a mix of running, gym work, or cross training. Runners with sensitive feet, mild foot health concerns, or who prefer a plush heel strike will value the certified diabetic-friendly design and APMA seal.

Those who need motion control or pronounced arch correction should look at stability models such as the Glycerin GTS 22 or other shoes specifically described as support or stability shoes, since this model emphasizes cushioning over corrective structure.

Pros & Cons

Pros

• Exceptional cushioning that eases impact without sacrificing toe-off responsiveness.
• Accommodating knit upper gives room in the toe box and a comfortable, breathable fit.
• Broad platform and tuned geometry deliver steady, smooth transitions through the gait cycle.
• Accepted by APMA and PDAC A5500 certified for diabetic-friendly design.

Cons

• High cushioning and certifications come with a price that some shoppers find steep.
• Runners needing added arch or motion control should choose a support-specific model instead.

Specifications

Model	Glycerin 22 (Women)
Support	Neutral
Midsole technology	DNA Tuned dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Ideal use	Road running, cross training, gym

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for women who prioritize plush cushioning, a roomy fit, and smooth heel-to-toe transitions. Its DNA Tuned midsole and medical endorsements make it especially suitable for runners with sensitive feet or those seeking added comfort; however, buyers needing strong corrective support should select a stability variant instead.

Frequently Asked Questions

Is the Glycerin 22 good for long runs?
Yes; the high level of cushioning and stable platform make it comfortable for longer road runs while helping reduce impact fatigue.

Does this shoe provide arch support?
It offers neutral support with cushioning that does not sacrifice basic arch comfort, but it is not a dedicated stability or motion-control shoe.

Is the upper tight or roomy?
The double jacquard knit upper is designed to be accommodating with extra room in the toe area and a padded heel for comfort.