Brooks Womens Glycerin 22 Neutral Running Shoe - Maximum Cushion

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a cushioning-first road shoe for women who prioritize plush comfort and smooth transitions. The Glycerin 22 stands out primarily for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver soft landings and energetic toe-offs, and it is also certified as a PDAC A5500 Diabetic shoe with the APMA Seal of Acceptance, underlining its supportive, foot-friendly design.

Key Features

• DNA Tuned cushion: Larger cells in the heel create soft, plush landings while smaller forefoot cells encourage a responsive toe-off for smoother gait transitions.
• Neutral support: Provides maximum cushioning without added corrective structure, making it suitable for runners who do not need medial support.
• Accommodating fit: The double jacquard knit upper stretches to fit a variety of foot shapes while remaining breathable and durable for long wear.
• Stable platform: A broad midsole platform stabilizes the foot and helps maintain smooth heel-to-toe movement during runs or walks.
• Medical-friendly certifications: PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance indicate attention to foot health and comfort.

Who It's For

The Glycerin 22 is ideal for women seeking maximum cushioning for road running, long walks, gym sessions, or everyday wear where comfort matters most. Runners with neutral gait who want a plush, stable ride and those needing a shoe cleared for diabetic-friendly wear will appreciate the thoughtful midsole geometry and certified fit.

Those who need significant medial support or corrective stability should consider a stability version such as the Glycerin GTS 22 instead, and runners who prefer a firmer, faster-feeling race shoe may find the Glycerin 22 too soft for tempo runs or speedwork.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact on knees and hips during long distances.
• Accommodating, breathable knit upper that provides a roomy toe box and reduces pressure points.
• Certifications for diabetic use and APMA acceptance support foot health considerations.
• Broad platform and tuned transitions make walking and easy runs feel smooth and stable.

Cons

• Sizing reports are mixed and some customers find they run small, so careful sizing is required.
• Maximum cushioning can feel bulky to runners who prefer a minimal or very responsive ride.

Specifications

Model	Glycerin 22
Gender	Women
Support	Neutral
Midsole tech	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong pick for women who want plush cushioning, a stable platform, and an accommodating fit for road running and long walks. Its medical-friendly certifications add confidence for foot health, and while sizing can be inconsistent, the shoe delivers excellent comfort and smooth transitions that make it a good value for cushioning-focused runners.

Frequently Asked Questions

Are these shoes suitable for long-distance running?
Yes, the Glycerin 22 offers plush cushioning and a stable platform that many runners find comfortable for long miles and extended walks.

Do these provide stability for overpronation?
No, this is a neutral shoe; runners needing added medial support should look at the Glycerin GTS 22 or other stability models.

How does the sizing run?
Sizing reports vary and some customers find them small, so try your usual size and consider ordering a half size up if you are between sizes.