Brooks Womens Glycerin 22 Neutral Running Shoe - Maximum Cushioning

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: runners and everyday gym users who want the most plush, neutral cushioning will appreciate these shoes. The Glycerin 22 focuses on a soft, responsive ride via Brooks' latest DNA Tuned midsole technology, delivering cushioned landings and energized toe-offs while keeping a broad, stable platform. It is also notable for diabetic-friendly certification and an APMA Seal of Acceptance, which adds confidence for buyers seeking foot health features.

Key Features

• Neutral Support: Delivers neutral support with maximal cushioning ideal for road running, cross training, or gym use without added correctional structure.
• DNA Tuned Cushion: Dual-size midsole cells create soft, plush heel landings and a responsive forefoot for smoother transitions.
• Accommodating Fit: The double jacquard knit upper provides stretch and breathability while remaining durable for regular training.
• Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and help produce stable heel-to-toe movement.
• Foot Health Certifications: Certified PDAC A5500 for diabetic shoe use and granted the APMA Seal of Acceptance for supportive design benefits.

Who It's For

The Glycerin 22 is best for women who prioritize cushioning and comfort over corrective support, including runners who log many miles on pavement and exercisers who want plush feel in cross training or gym sessions. Its roomy toe box and padded heel suit people who prefer an accommodating fit and like a softer landing.

Those needing firm motion control or heavy stability features should consider support-focused models instead, such as the Glycerin GTS variant, because the Glycerin 22 is explicitly a neutral shoe and emphasizes cushioning rather than pronation correction.

Pros & Cons

Pros

• Exceptional cushioning from DNA Tuned midsole design for comfortable long runs and recovery days.
• Accommodating double jacquard knit upper offers breathability and a flexible fit across the forefoot.
• Broad platform and tuned geometry provide stable, smooth heel-to-toe transitions.
• Certified for diabetic use and accepted by the APMA, adding confidence for foot health concerns.

Cons

• Maximal cushioning can feel bulky to runners who prefer a minimal or highly responsive lightweight shoe.
• Some buyers may find the price less appealing despite the build quality.

Specifications

Model	Glycerin 22
Gender	Women
Support type	Neutral
Midsole technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit
Health certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a top choice for women seeking maximum plush cushioning with a stable, neutral platform and an accommodating fit. Its DNA Tuned midsole and certified foot-health credentials make it a strong value for runners and gym users who prioritize comfort and supportive cushioning over corrective stability.

Frequently Asked Questions

Is the Glycerin 22 good for long road runs?
Yes. The plush DNA Tuned cushioning and stable platform make it well suited for long road miles and recovery runs.

Does it provide arch support for overpronation?
No. This is a neutral shoe; those needing extra support should look at stability variants such as the Glycerin GTS.

Is the shoe suitable for diabetic feet?
Yes. The model is certified PDAC A5500 and has the APMA Seal of Acceptance, indicating it meets criteria for diabetic-friendly features.