Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning 21

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a cushioning-first neutral trainer for runners and walkers who prioritize a soft, supportive ride. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver plush landings and responsive toe-offs, while the roomy toe box and accommodating double jacquard knit upper make it comfortable for long days on foot. For anyone seeking maximum cushioning with smooth transitions, this shoe delivers.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel absorb impact for soft landings while smaller forefoot cells encourage energetic toe-offs.
• Neutral Support: Designed for neutral runners, the shoe provides maximal cushioning without corrective structure, suitable for road running and gym use.
• Accommodating Fit: The double jacquard knit upper flexes with the foot and offers breathable durability for long walks or runs.
• Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and create a fluid heel-to-toe roll.
• Medical Acceptance: Certified as a PDAC A5500 Diabetic shoe and awarded the APMA Seal of Acceptance, signaling a design that supports foot health.

Who It's For

The Glycerin 22 is best for neutral road runners, walkers, and gym-goers who want maximum cushioning and a soft, plush sole for longer sessions. It is especially appropriate for people who value a roomy toe box and extra shock absorption for knees and hips.

Runners who need strong corrective support or who prefer a very firm, low-profile racing feel should look elsewhere; consider stability-specific models if overpronation is a concern. Those seeking a minimalist shoe for speed work will also likely find the Glycerin 22 too plush.

Pros & Cons

Pros

• Exceptional cushioning that makes long walks and runs feel less jarring on joints.
• Comfortable, breathable knit upper that adapts to foot shape for a forgiving fit.
• Smooth, stable heel-to-toe transitions thanks to the broad platform and tuned midsole.
• Recognized by medical groups as supportive for diabetic feet and overall foot health.

Cons

• Sizing opinions vary; some users report the shoe runs smaller than expected, so trying on or checking fit guidance is advisable.
• The maximal cushioning adds weight and a plush feel that may not suit speed-focused runners.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned
Upper	Double jacquard knit
Certifications	PDAC A5500 Diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who want maximum cushioning, a roomy toe box, and smooth transitions. It offers good value for anyone prioritizing comfort and joint protection, though those needing firm, lightweight race performance or added corrective support should consider other models.

Frequently Asked Questions

Do these shoes offer support for diabetic feet?
Yes, the Glycerin 22 is certified as a PDAC A5500 Diabetic shoe and carries the APMA Seal of Acceptance for foot health.

Are these shoes good for long runs?
Yes, the plush DNA Tuned cushioning and stable platform make them comfortable for long road runs and extended walks.

Do they run true to size?
Sizing feedback is mixed; some customers find them smaller than expected, so trying them on or reviewing the brand size chart is recommended.