Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning been

Our review of the Brooks Womens Glycerin 22 finds it best for runners and everyday athletes who want maximal cushioning without extra motion control. The biggest reason to buy is the shoe's updated midsole, which uses DNA Tuned technology to combine soft landings with energetic toe-offs, delivering a noticeably smoother heel-to-toe transition than the Glycerin 21. The Glycerin 22 also arrives as a certified PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, which reinforces its comfort and foot-health credentials.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide plush landings while smaller forefoot cells invite responsive, energetic toe-offs for balanced runs.
• Neutral Support: Designed for neutral runners, the shoe offers the maximum amount of cushioning without added stability elements that change gait mechanics.
• Accommodating Fit: The new double jacquard knit upper stretches and breathes, giving a roomy toe box and a comfortable heel wrap for long wear.
• Smooth Transitions: A broad platform plus tuned heel and forefoot smooth heel-to-toe motion and help maintain stability through the stride.
• Medical Acceptance: Certified PDAC A5500 and APMA-accepted, signaling suitability for diabetic feet and people prioritizing foot health.

Who It's For

The Glycerin 22 is ideal for road runners, gym-goers, and cross training athletes who prioritize cushioning and comfort over corrective support. Runners who like a plush ride, plenty of toe room, and a padded heel will find the shoe particularly appealing, especially those who appreciated the Glycerin 21 and want a softer, more refined midsole feel.

Those who need strong motion control or structured support should look at the Glycerin GTS 22 or other stability models, since this is explicitly a neutral running shoe. Also, minimalists or racers seeking a lightweight, low-profile racer would likely prefer a different, less-cushioned option.

Pros & Cons

Pros

• Exceptional cushioning that does not sacrifice a responsive toe-off thanks to DNA Tuned.
• Comfortable, breathable knit upper that provides plenty of room in the toe box.
• Certified PDAC A5500 and APMA Seal of Acceptance for added foot-health confidence.

Cons

• Heavily cushioned feel may be too soft for runners who prefer firmer, faster shoes.
• Some customers find the price higher than expected for the category.

Specifications

Brand	Brooks
Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Medical certification	PDAC A5500 certified; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a top choice for runners who want a plush, comfortable ride with thoughtful engineering around transitions and foot health. It is good value for anyone who prioritizes cushioning, a roomy fit, and medical-minded acceptance; runners seeking firmer responsiveness or built-in stability should evaluate alternative models.

Frequently Asked Questions

Is the Glycerin 22 good for long runs?
The generous cushioning and smooth transitions make it well suited to long road runs, especially for neutral runners who want comfort over speed.

Does it offer arch support?
It provides neutral support with cushioning; it maintains some arch support feel but is not a stability shoe for overpronation.

How does the fit compare to previous versions?
The double jacquard knit upper offers a more accommodating, breathable fit compared with the predecessor, with extra room in the toe box and a padded heel.