Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning DNA

In this review the Brooks Womens Glycerin 22 neutral running shoe is presented as a go-to option for runners and walkers who prioritize maximum cushioning and smooth transitions. The main reason to consider these shoes is their updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells to create a soft landing and responsive toe-off. They are APMA accepted and certified as a PDAC A5500 diabetic shoe, making them a strong choice for anyone seeking plush comfort with medical-friendly credentials.

Key Features

• Neutral support: Designed for neutral runners, the shoe provides the maximum amount of cushioning without added stability technologies that change gait mechanics.
• DNA Tuned cushion: The midsole uses dual-size cells with larger heel cells for soft landings and smaller forefoot cells for energetic toe-offs.
• Accommodating fit: A double jacquard knit upper offers flexibility and breathability while adapting to different foot shapes.
• Smooth transitions: A broad platform plus tuned heel and forefoot promote stable, smooth heel-to-toe movement on roads and treadmills.
• Medical and podiatry recognition: Certified PDAC A5500 and granted the APMA Seal of Acceptance, supporting use by customers with diabetic footwear needs.

Who It's For

The Brooks Womens Glycerin 22 is ideal for road runners, daily walkers, and gym-goers who want plush cushioning and a soft ride, including those who need a diabetic-friendly shoe thanks to its PDAC A5500 certification. Runners who value a roomy toe box and supportive cushioning for knees and hips will find the shoe comfortable for long walks and recovery runs.

Those who prefer a firm, performance-oriented race shoe or who need structured motion control should look elsewhere; if you require extra medial support, consider Brooks models with support features. Also note that sizing reports vary, so trying a size up or checking retailer return policies is prudent.

Pros & Cons

Pros

• Exceptional cushioning that absorbs impact and helps reduce knee and hip discomfort on long walks.
• Breathable, flexible knit upper that adapts to the foot for a comfortable fit.
• Stable, broad platform and tuned geometry that create smooth heel-to-toe transitions.
• Recognized by APMA and certified PDAC A5500, suitable for diabetic footwear requirements.

Cons

• Sizing can run small for some shoppers, so fit varies and may require ordering a half or full size up.
• As a maximal cushion neutral shoe, it is not the best choice for runners seeking aggressive responsiveness or strong motion control.

Specifications

Brand	Brooks
Model	Glycerin 22
Support	Neutral
Cushioning	DNA Tuned dual-cell midsole
Upper	Double jacquard knit, breathable and flexible
Medical recognition	PDAC A5500 certified; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, comfort, and smooth transitions, and it delivers added confidence for diabetic customers through PDAC certification. While sizing can vary, the combination of DNA Tuned cushioning and an accommodating knit upper makes this shoe good value for anyone seeking a soft, supportive daily trainer rather than a race-day performance shoe.

Frequently Asked Questions

Do these shoes provide arch support?
The Glycerin 22 offers neutral support with substantial cushioning but does not include strong motion-control or medial posting; those needing extra arch support should consider a stability model.

Are these shoes suitable for diabetic feet?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating it meets criteria for diabetic-friendly footwear.

How do they fit compared with previous versions?
They retain a roomy toe box and an accommodating knit upper, but some customers report sizing runs small compared with prior models, so trying a larger size may be necessary.