Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning foot

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum plush cushioning with smooth transitions. The standout reason to consider the Glycerin 22 is its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver a soft landing and an energetic toe-off, making long miles or long days on your feet noticeably less fatiguing. The shoe is also certified for diabetic use and carries the APMA Seal of Acceptance, which reinforces its focus on comfort and foot health.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide plush, soft landings while smaller forefoot cells push off responsively for smoother strides.
• Neutral Support: Built for neutral runners seeking the maximum amount of cushioning without added stability posts, suitable for road running and cross training.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce hot spots and adapt to foot shape over long wear periods.
• Stability Through Platform: A broad midsole platform and tuned heel/forefoot promote smooth heel-to-toe transitions and a steady ride.
• Medical and Podiatric Approval: Certified PDAC A5500 as a diabetic shoe and given the APMA Seal of Acceptance, indicating attention to foot health and fit.

Who It's For

The Glycerin 22 is aimed at women who prioritize cushioning and comfort: road runners logging moderate to long distances, walkers spending hours on hard surfaces, or gym goers who prefer a soft, supportive sole. Its neutral platform suits those without strong pronation needs who want a plush, protective ride.

Runners who need firm stability or custom orthotic-specific fit might consider models with added support; if you require a support-focused option in the same family, look at the Glycerin GTS version for guidance. Also note that sizing opinions vary among users, so trying on or checking return policies is recommended.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that reduces impact on knees and hips during long walks or runs.
• Breathable, accommodating knit upper that provides a roomy toe box for comfort.
• Certified for diabetic use and APMA-accepted, adding confidence for foot-health conscious buyers.
• Smooth, stable transitions due to a broad platform and tuned heel and forefoot.

Cons

• Sizing feedback is mixed among customers, with some reporting the shoe runs smaller than expected, so sizing may require care.
• Rearfoot-focused plushness may feel too soft for runners who prefer a firmer, more responsive ride.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with variable cell sizing
Upper	Double jacquard knit, breathable and accommodating
Approvals	PDAC A5500 diabetic certification; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for women who want top-tier cushioning and a smooth, stable ride for road running, walking, or gym use; its certified foot-health credentials add value for those concerned about comfort over long wear. If you need maximal support or a firmer feel, consider a stability variant, but for plush protection and breathable fit the Glycerin 22 represents solid value.

Frequently Asked Questions

Are these shoes good for long walks?
Yes, customers report they can walk long distances comfortably thanks to the plush cushioning and supportive platform.

Do they provide arch support?
The Glycerin 22 is a neutral shoe with generous cushioning rather than pronounced arch correction; those needing extra support should consider a stability version.

How does sizing run?
Sizing feedback is mixed; some customers find them small, so trying your normal running size or checking return policy is advised.