Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning has

In this review the Brooks Womens Glycerin 22 stands out as a top pick for runners and walkers who prioritize cushion and smooth transitions. The shoe's single biggest selling point is its DNA Tuned midsole, which combines larger heel cells with smaller forefoot cells to deliver a soft landing and energetic toe-off; reviewers consistently highlight the comfort and support that lets them walk long distances or run without pain. It is also notable for being a certified PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, which reinforces its credibility for people needing foot-friendly footwear.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel create plush landings while smaller forefoot cells add responsive toe-offs for a balanced ride.
• Neutral Support: Designed as a neutral shoe that provides the maximum amount of cushioning, making it suitable for road running and general training.
• Accommodating Fit: The double jacquard knit upper stretches to conform to the foot, offering breathability and a roomy toe box for comfort on long outings.
• Smooth Transitions: A broad platform combined with tuned heel and forefoot geometry stabilizes the foot and smooths heel-to-toe movement.
• Medical Approvals: Certified PDAC A5500 for diabetic use and carries the APMA Seal of Acceptance, signaling suitability for sensitive feet.

Who It's For

The Glycerin 22 is best for women who want plush cushioning and an accommodating fit for road running, long walks, gym sessions, or everyday wear. Runners who value a soft, stable ride and pedestrians who need supportive shoes for knee or hip comfort will appreciate the DNA Tuned midsole and broad platform.

Those who need strong stability or corrective motion control should look elsewhere, such as models with added guidance or support features; the Glycerin 22 is a neutral shoe and pairs less well with highly structured orthotics unless sized carefully.

Pros & Cons

Pros

• Excellent soft cushioning and responsive toe-offs thanks to DNA Tuned midsole technology.
• Roomy, breathable double jacquard knit upper that accommodates wider forefeet comfortably.
• Certified PDAC A5500 and APMA accepted, making it a dependable option for those needing foot-friendly design.
• Broad platform offers stable transitions and good support for long-distance walking or running.

Cons

• Sizing reports vary, with some customers finding them smaller than expected, so careful sizing or trying on is recommended.
• As a neutral shoe, it lacks the extra corrective support some overpronators may require.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Cushioning	DNA Tuned midsole with larger heel cells
Upper	Double jacquard knit, breathable and accommodating
Medical Certifications	PDAC A5500 certified; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for women who want maximum cushioning, a comfortable roomy fit, and smooth, stable transitions for road running or long walks. Its medical certifications and well-executed DNA Tuned cushioning give it good value for anyone prioritizing comfort and foot health, though shoppers should confirm sizing before buying.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers report comfortable, pain-free long-distance walking thanks to the plush cushioning and stable platform.

Do they provide corrective support for overpronation?
No. The Glycerin 22 is a neutral support shoe; runners needing motion control should choose a stability model instead.

How do they fit?
The double jacquard knit upper is accommodating and breathable, but sizing reports vary so trying them on or checking the retailer size guidance is advised.