Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning IS

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a premium, highly cushioned neutral trainer best for runners and walkers who prioritize plush comfort and smooth transitions. The shoe's standout feature is its DNA Tuned midsole that blends dual-size cells for a soft, roomier landing in the heel and a responsive toe-off, and it carries both APMA acceptance and PDAC A5500 diabetic shoe certification, which underlines the focus on comfort and support for sensitive feet.

Key Features

• DNA Tuned Cushion: Dual-size cells create a soft, plush heel strike and a responsive forefoot for smoother stride transitions.
• Neutral Support: Designed as a neutral shoe, it provides maximum cushioning without added stability elements, ideal for natural foot motion.
• Accommodating Fit: The double jacquard knit upper offers flexible stretch and breathability while maintaining durability for long wear.
• Stable Platform: A broad midsole platform stabilizes the foot through heel-to-toe movement to reduce wobble on road surfaces.
• Medical Certifications: Certified as a PDAC A5500 diabetic shoe and awarded the APMA Seal of Acceptance for foot health and comfort.

Who It's For

The Glycerin 22 is best for women who want maximum cushioning for road running, long walking sessions, the gym, or cross training where a plush ride matters more than corrective support. Runners with knee or hip sensitivity who benefit from extra shock absorption will find the soft midsole and roomy toe box particularly appealing.

Those who need firm motion control or corrective stability should look at Brooks Glycerin GTS 22 or other stability models, since the Glycerin 22 is explicitly a neutral shoe. Also, shoppers who need a precise, narrow fit may need to size carefully, as customer feedback shows mixed impressions on true-to-size fit.

Pros & Cons

Pros

• Exceptional cushioning that makes long walks and runs feel less jarring on knees and hips.
• Supportive, broad platform and tuned transitions that promote a smooth heel-to-toe roll.
• Breathable, flexible double jacquard knit upper that accommodates a range of foot shapes.
• Recognized by APMA and certified PDAC A5500, adding confidence for sensitive-feet users.

Cons

• Sizing feedback is mixed, with some customers reporting the shoe runs small, so trying a half size up may be necessary.
• Because the shoe prioritizes plush cushioning, it may feel too soft for runners who prefer a firmer, race-oriented ride.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe
Ideal Uses	Road running, walking, cross training, gym

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for women seeking maximum cushioning and smooth transitions during runs or long periods on their feet; its DNA Tuned midsole and accommodating knit upper deliver comfort and support, and the medical certifications add reassurance for sensitive-foot needs, making it good value for those who prioritize plush comfort over firm responsiveness.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The plush DNA Tuned cushioning and broad platform make the Glycerin 22 comfortable for long distance walking and reduce impact on knees.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; users who need added support should consider the Glycerin GTS 22 or a stability model.

How does sizing run?
Customer reports are mixed; some find them small, so consider trying a half size up if between sizes or if you prefer extra toe-room.