Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning Seal

In this review the Brooks Womens Glycerin 22 Neutral Running Shoe stands out for runners and walkers who prioritize a soft, protective ride. The single biggest reason to consider the Glycerin 22 is the DNA Tuned midsole that blends larger heel cells for plush landings with smaller forefoot cells for responsive toe-offs, creating a smooth, evenly cushioned transition from heel to toe. The shoe is also certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, reinforcing its suitability for people needing supportive, well-cushioned footwear.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells deliver energetic toe-offs for a balanced stride.
• Neutral Support: Designed for neutral runners, the shoe offers maximum cushioning without added stability elements, ideal for road running and gym use.
• Accommodating Fit: The double jacquard knit upper flexes with the foot for breathable comfort and a roomy toe box.
• Smooth Transitions: A broad platform and tuned heel/forefoot promote stable, smooth heel-to-toe roll during longer walks or runs.
• Medical and Podiatric Acceptance: Certified PDAC A5500 and APMA-accepted, giving added confidence for those needing diabetic-friendly or podiatrist-recommended footwear.

Who It's For

The Glycerin 22 is best for neutral road runners, walkers, and gym-goers who want maximum cushioning and a plush ride. Its certified diabetic-friendly construction and roomy fit also make it a practical option for people who need extra foot protection and comfort during extended periods of standing or walking.

Runners who need motion control or pronounced stability should look at other models, such as a GTS variant, because the Glycerin 22 intentionally provides neutral support rather than corrective guidance. Those seeking a very snug, race-day shoe may find the Glycerin 22 heavier and softer than minimalist or racing options.

Pros & Cons

Pros

• Excellent cushioning that absorbs impact and helps protect knees and hips during long walks.
• Comfortable, breathable knit upper with a roomy toe box for natural toe splay.
• Stable broad platform and tuned transitions reduce harsh heel strikes and create a smooth gait.
• Certified PDAC A5500 and APMA Seal of Acceptance add medical credibility for sensitive feet.

Cons

• Sizing can be inconsistent for some wearers, with reports of runs very small, so trying before buying or checking return policies is wise.
• The shoe prioritizes cushioning over responsiveness, so it may feel less lively for tempo runs or racing.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable
Medical Certification	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for neutral runners and anyone who values plush cushioning and smooth transitions. Its DNA Tuned midsole and broad platform deliver lasting comfort and stability, and the medical certifications make it a responsible option for sensitive feet. It represents good value for those who prioritize protection and everyday comfort over lightweight speed.

Frequently Asked Questions

Are these shoes good for walking long distances?
Yes. The plush cushioning and stable platform make the Glycerin 22 comfortable for extended walking and standing.

Do these shoes provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing added support should consider a GTS or stability model.

Do they run true to size?
Some customers report inconsistent sizing and a tendency to run small, so sizing up or checking return options is recommended.