Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Cushioning you

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum, plush cushioning without added stability corrections. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs, and it carries both PDAC A5500 diabetic certification and the APMA Seal of Acceptance. If your priority is a luxurious, well-cushioned ride and an accommodating upper that breathes, this shoe makes a strong case.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel give soft, plush landings while smaller forefoot cells promote more responsive toe-offs for smoother transitions.
• Neutral Support: Designed as a neutral shoe, it provides the maximum amount of cushioning without adding medial support, ideal for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce hotspots and comfortably house a roomy toe box.
• Smooth, Stable Transitions: A broad platform combined with tuned heel and forefoot geometry stabilizes the foot and eases heel-to-toe movement.
• Medical and Professional Acceptance: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, indicating attention to foot health and safety.

Who It's For

The Glycerin 22 is best for road runners, gym goers, and walkers who prioritize cushioning, comfort, and foot health certifications. It suits people who cover moderate to long distances on pavement or treadmill and those who need a plush sole that helps protect knees and hips during long walks.

Runners who need strong stability or motion control should look elsewhere, for example at the Glycerin GTS line, which keeps a similar feel but adds support. Also, anyone who prefers a very firm, race-oriented ride may find this shoe too soft for fast tempos.

Pros & Cons

Pros

• Excellent cushioning that makes long walks and runs feel less jarring on knees and hips.
• Comfortable, roomy toe box and breathable knit upper that adapts to foot shape.
• Medical certifications like PDAC A5500 and APMA Seal of Acceptance support foot health use.
• Broad platform and tuned geometry deliver smooth, stable transitions.

Cons

• Sizing reports vary; some users find these run smaller than expected so trying sizing carefully is recommended.
• Neutral design lacks built-in support for severe overpronation.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for runners and walkers seeking plush, protective cushioning and an accommodating fit backed by foot health certifications. It represents good value for anyone prioritizing comfort and smooth transitions, though those needing firm, race-style responsiveness or extra stability should consider alternatives.

Frequently Asked Questions

Do these run true to size?
Sizing opinions vary; some users report they run small, so try on or size up if you are between sizes.

Are these suitable for long-distance road running?
Yes, the maximum cushioning and stable platform make them well suited for longer road miles and extended walks.

Is there a version with added support?
Yes, the Glycerin GTS 22 offers a similar ride with added support for those who need motion control.