Brooks Womens Glycerin 22 Neutral Running Shoe - Plush Neutral Cushion

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is clear: this shoe is for women who want maximum cushioning with neutral support for road running and everyday wear. The biggest reason to buy is the updated DNA Tuned cushion, which pairs soft landings in the heel with responsive toe-offs for smoother transitions. It is also noteworthy that this model is certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, making it a sensible pick for walkers or runners prioritizing foot health.

Key Features

• Neutral support: Delivers the maximum amount of cushioning while maintaining a neutral platform suited to road running, gym sessions, and cross training.
• DNA Tuned cushion: Larger midsole cells in the heel create plush landings while smaller forefoot cells promote energetic toe-offs for a balanced ride.
• Accommodating fit: The double jacquard knit upper flexes around the foot for breathable comfort and a roomy toe box that reduces pressure points.
• Smooth transitions: A broad platform and tuned heel and forefoot stabilize the foot and smooth heel-to-toe movement.
• Health certifications: Certified PDAC A5500 and APMA-accepted, which supports use by those needing diabetic or podiatric-friendly footwear.

Who It's For

The Glycerin 22 is best for women who prioritize plush cushioning and comfortable daily wear: long walks, easy runs on pavement, and cross training where shock absorption and foot comfort matter. Runners with neutral pronation who need a soft underfoot feel but still want some responsiveness will appreciate the DNA Tuned midsole.

Those who need strong motion control or heavy stability features should look elsewhere, such as a GTS or stability model, since this shoe focuses on neutral support. Also, buyers sensitive to precise sizing should try them on first because customers report mixed sizing experiences.

Pros & Cons

Pros

• Exceptional underfoot cushioning that absorbs impact and supports long walks without pain.
• Accommodating knit upper offers a breathable, comfortable fit and a roomy toe box.
• Stable, broad platform and tuned transitions make gait feel smooth from heel to toe.

Cons

• Sizing appears inconsistent across reports, so some customers find them smaller than expected.

Specifications

Brand	Brooks
Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for women seeking plush, neutral cushioning and a breathable, accommodating fit for road running and daily wear. Its DNA Tuned midsole and broad platform deliver smooth, stable transitions, and the diabetic- and podiatry-friendly certifications add real value for those concerned about foot health.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers report comfortable long-distance walking thanks to the soft cushioning and roomy toe box.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners who need added support should consider a stability or GTS model.

Do they run true to size?
Sizing is mixed in customer feedback, so trying them on or checking the retailer's sizing notes is recommended before purchase.