Brooks Womens Glycerin 22 Neutral Running Shoe - Plush, Smooth Ride

In this review the Brooks Womens Glycerin 22 Neutral Running Shoe earns its place as a go-to option for runners and gym users who prioritize maximum cushioning and smooth transitions. The single biggest reason to buy is its updated DNA Tuned cushion, which balances soft landings with responsive toe-offs for a plush but energetic feel, and the shoe's certifications - PDAC A5500 diabetic-friendly fit and the APMA Seal - add real reassurance for anyone who needs accommodating footspace and clinically minded design.

Key Features

• Neutral support: Delivers a high level of cushioning without added stability structure, making it ideal for neutral runners or anyone seeking plush daily trainers.
• DNA Tuned cushion: Larger midsole cells in the heel create soft landings while smaller forefoot cells encourage responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed and breathes well while remaining durable for repeated road miles.
• Stable platform: A broad sole base stabilizes the foot and works with the tuned heel and forefoot to reduce abrupt heel-to-toe shifts.
• Medical-friendly design: Certified PDAC A5500 and APMA-accepted, which supports users who need roomier toe boxes and thoughtful internal shaping.

Who It's For

The Glycerin 22 suits neutral runners, road joggers, and cross trainers who want the maximum cushioning available in this Brooks line without added motion control. It is a solid choice for people who spend long periods on their feet, use the shoe for gym sessions, or need an accommodating toe box and padded heel for daily comfort.

Those who need strong corrective support for overpronation should look at the Glycerin GTS 22 or other stability models, and runners who prefer a minimal, low-drop ride may find the thick cushioning too soft for tempo work or fast racing.

Pros & Cons

Pros

• Exceptional cushioning that still offers a responsive toe-off thanks to the DNA Tuned midsole.
• Comfortable, roomy fit with a breathable double jacquard knit upper that accommodates different foot shapes.
• Stable, wide platform that promotes smooth heel-to-toe transitions for relaxed road miles or gym wear.
• Certified PDAC A5500 and APMA Seal of Acceptance add confidence for foot health and diabetic-friendly use.

Cons

• Heavier, highly cushioned construction may not suit runners seeking a lightweight race shoe or very firm ride.
• Some buyers note sticker shock on price even while acknowledging good build quality.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for runners and active users who prioritize plush cushioning, a roomy fit, and smooth transitions. Its DNA Tuned midsole and stable platform make it especially good for longer easy runs, recovery days, and daily wear; those wanting lightweight race performance or aggressive stability should consider alternatives.

Frequently Asked Questions

Are these shoes good for people with diabetes?
Yes, the Glycerin 22 is certified PDAC A5500 and is designed with an accommodating internal shape suitable for diabetic-friendly footwear needs.

Do they offer enough support for overpronation?
They are a neutral shoe; runners who need added support should consider the Glycerin GTS 22 or dedicated stability models.

How does the fit run?
Customers report a roomy toe box and a well-padded heel that provide comfortable cushioning and accommodate several foot shapes.