Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 13DQ)

Our review of the Brooks Womens Glycerin 22 finds it best suited to runners and walkers who prioritize a soft, highly cushioned ride and a forgiving, roomy fit. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells for plush landings with smaller forefoot cells for lively toe-offs, delivering both comfort and forward propulsion on road runs or long walks. Certified as a PDAC A5500 diabetic shoe and bearing the APMA Seal of Acceptance, it also reassures anyone seeking medical-grade cushioning and supportive construction.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells encourage responsive toe-offs for smoother transitions.
• Neutral Support: Designed for neutral runners, it offers the maximum level of cushioning without added motion control for a comfortable, natural stride.
• Accommodating Fit: The double jacquard knit upper stretches to fit wider feet and toes while maintaining breathability and durability for daily use.
• Smooth Transitions: A broad platform and tuned heel/forefoot geometry stabilize the foot and help the gait move from heel to toe smoothly.
• Medical Certifications: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance, supporting foot health for sensitive users.

Who It's For

The Glycerin 22 is ideal for road runners, gym-goers, and walkers who want maximum cushioning and a plush underfoot feel without extra support features; it works well for longer easy runs, recovery days, and extended periods on foot where comfort matters. Its certifications also make it a sensible option for people managing foot sensitivity or diabetes who need a vetted, cushioned shoe.

Runners who need corrective support for severe overpronation should look elsewhere, such as stability models; also, shoppers who require a very snug, race-oriented fit may prefer a lighter, more performance-focused shoe instead of this plush, neutral trainer.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that supports long walks and runs without pain.
• Roomy toe box and accommodating knit upper that reduce pressure on toes and forefoot.
• Certified PDAC A5500 and APMA Seal give confidence for foot health and medical use.

Cons

• Sizing feedback is mixed from customers, with some reporting they run small, so trying on or checking fit is recommended.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, stable transitions, and an accommodating fit backed by medical certifications. Its DNA Tuned midsole and roomy knit upper deliver comfort and durability, making it good value for anyone prioritizing daily comfort and foot health over lightweight performance.

Frequently Asked Questions

Are these shoes good for long-distance walking?
Yes, the plush DNA Tuned cushioning and broad platform make them comfortable for long walks and extended standing.

Do they provide stability for overpronation?
No, the Glycerin 22 is a neutral shoe; runners needing stability should consider Brooks models with added support.

Do they run true to size?
Customer reports vary; some find them small, so trying them on or checking sizing guidance is recommended.