Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 16LV)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and walkers who prioritize a soft, protective ride. The single biggest reason to buy is the updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells for noticeably plush landings and responsive toe-offs. The shoe is also certified as a diabetic-friendly option and carries the APMA Seal of Acceptance, making it a solid pick when foot health and comfortable long miles matter.

Key Features

• Neutral support: Provides maximum cushioning without added stability elements, making it suited to neutral runners and everyday gym use.
• DNA Tuned cushion: Larger midsole cells in the heel deliver soft landings while smaller forefoot cells encourage a springy, energetic toe-off.
• Accommodating fit: The double jacquard knit upper stretches where needed and breathes well for longer wear and varied foot shapes.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry help stabilize the foot and smooth heel-to-toe movement.
• Medical endorsements: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, supporting foot health concerns.

Who It's For

The Glycerin 22 is aimed at women who want a highly cushioned, neutral running shoe for road miles, cross training, gym sessions, or long days on their feet. It is especially useful for those who need extra protection for knees or hips, and for people who appreciate a roomy toe box and soft midsole feel.

Shoppers who require pronounced stability or corrective support should look at stability-specific models instead, and those who prefer a sharply responsive, minimal feel might find the plush cushioning too soft for fast tempo runs.

Pros & Cons

Pros

• Exceptional cushioning and comfortable landings thanks to the DNA Tuned midsole design.
• Accommodating knit upper that balances breathability and fit for longer wear.
• Medical certifications offer reassurance for diabetic customers and those focused on foot health.
• Stable, broad platform that smooths transitions from heel to toe.

Cons

• Sizing reports vary, with some customers finding the shoe smaller than expected, so trying on before buying is recommended.
• The ultra-plush feel may not appeal to runners who prefer a firm, performance-focused ride.

Specifications

Brand	Brooks
Model	Glycerin 22 (Womens)
Support type	Neutral
Midsole technology	DNA Tuned with varied cell sizes
Upper	Double jacquard knit for breathability
Medical endorsements	PDAC A5500 certified; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for women seeking plush, protective cushioning and a comfortable, accommodating fit for road running, gym work, or all-day walking. With medical certifications and a focus on smooth transitions, it delivers good value for runners who prioritize comfort over a firm, race-oriented feel.

Frequently Asked Questions

Are these shoes good for long-distance walking?
Yes; the generous cushioning and broad platform make them comfortable for long walks and standing periods.

Do they provide stability for overpronation?
No; the Glycerin 22 is a neutral shoe-those needing added support should consider stability models instead.

Do they run true to size?
Sizing feedback is mixed and some report they run small, so trying them on or checking specific retailer sizing guidance is recommended.