Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 16VG)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, highly cushioned neutral trainer best suited for women who prioritize comfort on roads, in the gym, or for long walks. The single biggest reason to buy is the latest DNA Tuned midsole that blends larger heel cells and smaller forefoot cells to create soft landings and responsive toe-offs, delivering a noticeably smooth ride compared with the predecessor Glycerin 21.

Key Features

• Neutral Support: Provides maximum cushioning without added stability elements, making it ideal for runners who do not need corrective support.
• DNA Tuned Cushion: Larger heel cells supply plush, soft landings while smaller forefoot cells promote a lively toe-off for smoother transitions.
• Accommodating Fit: The double jacquard knit upper flexes and breathes, giving a roomy, comfortable feel especially in the toe box area.
• Smooth Transitions: A broad platform and tuned heel and forefoot create steady, stable heel-to-toe movement on pavement and treadmills.
• Medical Acceptance: Certified as a PDAC A5500 Diabetic shoe and awarded the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 is aimed at runners and walkers seeking plush cushioning for road running, long-distance walking, or cross training who want a neutral shoe with maximum softness. It suits people with knee or hip sensitivity who benefit from a soft midsole and a broad, stabilizing platform.

Those who need firm corrective support or very precise race-day responsiveness should look elsewhere, for example the Brooks Glycerin GTS 22 if added support is required, or a lighter performance trainer for speed-focused runs.

Pros & Cons

Pros

• Exceptional comfort and cushioning that customers report reduces pain on long walks and supports knees and hips.
• Breathable, flexible double jacquard knit upper for a comfortable, accommodating fit and roomy toe box.
• Stable broad platform with tuned heel and forefoot for smooth heel-to-toe transitions.
• Recognized health credentials with PDAC A5500 certification and APMA Seal of Acceptance.

Cons

• Sizing appears inconsistent for some buyers, with reports that certain pairs run smaller than expected.
• Maximum cushioning adds weight compared with light performance trainers, which may not suit speed-focused runners.

Specifications

Brand	Brooks
Model	Glycerin 22 (women)
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Glycerin 22 is a strong choice for women who want plush, protective cushioning and a comfortable, roomy fit for road running, walking, and gym work. Its DNA Tuned midsole and broad platform deliver smooth, stable transitions and excellent support for knees and hips, making it good value for anyone who prioritizes comfort over lightweight speed.

Frequently Asked Questions

Do these run true to size?
Some customers report they run smaller than expected, so consider trying on or ordering your usual size with an exchange option available.

Is this shoe good for people with foot health concerns?
Yes, it is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating suitability for diabetic foot needs and general foot health.

Can I use these for speed training?
They are best for cushioned road runs and long efforts; heavier cushioning makes them less ideal for fast race-pace training.