Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 25YP)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and everyday walkers who prioritize plush cushioning and smooth transitions. This shoe stands out as a neutral trainer with the latest DNA Tuned cushion midsole that combines larger heel cells and smaller forefoot cells for soft landings and energetic toe-offs. It is also certified as a PDAC A5500 Diabetic shoe and carries the APMA Seal of Acceptance, which will appeal to buyers seeking documented foot health benefits alongside maximum cushioning.

Key Features

• DNA Tuned Cushion: Dual-size midsole cells create a soft, plush heel strike while the firmer forefoot cells encourage a responsive toe-off for smoother gait transitions.
• Neutral Support: Designed as a neutral shoe that delivers the maximum amount of cushioning, making it suitable for road running, cross training, and gym sessions.
• Accommodating Fit: The engineered double jacquard knit upper flexes to the foot for breathability and comfort without feeling overly tight.
• Stability Through Platform: A broad midsole platform and tuned heel/forefoot design stabilize the foot and help produce steady heel-to-toe movement.
• Health Certifications: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, lending confidence for foot health concerns.

Who It's For

The Glycerin 22 is aimed at women who want maximum cushioning in a neutral shoe, whether they spend hours walking, log easy road runs, or do mixed gym workouts. The soft midsole and roomy toe box suit those who need comfort for long periods on their feet or who appreciate extra shock absorption for knee and hip support.

Runners who need strong motion control or pronounced support should look at a stability sibling instead, such as the Glycerin GTS 22. Also, buyers who require a precise, narrow fit may find the accommodating knit upper feels roomier than expected, so sizing and fit attention is advised.

Pros & Cons

Pros

• Exceptional cushioning that protects knees and hips during long walks and easy runs.
• Breathable, flexible double jacquard knit upper provides a comfortable, accommodating fit.
• Smooth, stable transitions from heel to toe thanks to the broad platform and tuned midsole.

Cons

• Sizing reports vary and some wearers find the shoe runs small, so ordering carefully or trying on first is recommended.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a solid choice for anyone seeking top-tier cushioning and a smooth ride in a neutral trainer; its health certifications add confidence for sensitive feet. It represents good value for walkers and runners who prioritize comfort and stable transitions, though shoppers should verify sizing before purchase.

Frequently Asked Questions

Are these shoes suitable for long-distance walking?
Yes, the soft midsole and roomy toe box make the Glycerin 22 comfortable for long-distance walking and extended wear.

Do these provide stability for overpronation?
No, the Glycerin 22 is a neutral shoe; those needing added support should consider the Glycerin GTS 22 or a stability model.

How does the fit compare to prior versions?
The upper is an engineered double jacquard knit that is more accommodating, but sizing reports vary so trying on or checking fit guidance is recommended.