Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 3J45)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and gym-goers who prioritize maximum cushioning without extra stability features. The standout reason to buy is the updated DNA Tuned cushion, which blends larger heel cells for a soft landing with smaller forefoot cells for a responsive toe-off, delivering a smooth ride on roads and treadmills. It also carries the PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance, making comfort and foot health a clear focus in everyday training and long runs.

Key Features

• Neutral support: Designed to provide neutral support while offering the maximum amount of cushioning, ideal for runners who do not need motion control.
• DNA Tuned cushion: Dual-size midsole cells create plush landings at the heel and energetic toe-offs in the forefoot for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed for comfort while providing breathability and durability.
• Smooth transitions: A broad platform plus a tuned heel and forefoot stabilizes the foot and eases heel-to-toe movement.
• Medical endorsements: Certified PDAC A5500 and APMA accepted, which supports use by those needing extra foot-care credentials.

Who It's For

The Glycerin 22 suits neutral runners, road runners, cross-training athletes, and anyone who spends time on the treadmill or in the gym and wants maximum cushioning and a breathable, flexible upper. It's a solid pick for those with sensitive feet who appreciate a roomy toe box and padded heel.

Runners who require pronounced stability or corrective support should look at models with added guidance features, while minimalists seeking a very lightweight, low-stack shoe may prefer a different style. Those who want a similar feel with added support can compare the Glycerin GTS 22.

Pros & Cons

Pros

• Generous cushioning that many customers describe as comfortable for long runs and daily wear.
• Accommodating knit upper gives a roomy, breathable fit without sacrificing durability.
• Certified for diabetic use and APMA accepted, providing reassurance for foot-care needs.
• Stable broad platform and tuned midsole promote smooth heel-to-toe transitions.

Cons

• Some buyers feel the price is high relative to expectations, even when quality is noted.
• Neutral support means it is not the best choice for runners needing extra motion control.

Specifications

Brand	Brooks
Model	Glycerin 22
Support type	Neutral
Midsole tech	DNA Tuned dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a top choice for neutral runners and regular gym users who want plush cushioning, an accommodating fit, and medically endorsed comfort. It represents good value for anyone prioritizing long-wear comfort and smooth transitions, though shoppers needing corrective support should consider stability-specific alternatives.

Frequently Asked Questions

Are these shoes good for long runs?
Yes; the abundant cushioning and smooth transitions make the Glycerin 22 comfortable for extended road runs and treadmill sessions.

Do they offer arch support?
They provide neutral support with reasonable arch comfort, but they are not a corrective stability shoe for overpronation.

Are they suitable for diabetic feet?
Yes; the Glycerin 22 is certified PDAC A5500 and has the APMA Seal of Acceptance, indicating suitability for many diabetic users.