Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 3X78)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and active women who want maximum cushioning without added stability hardware. The standout reason to consider these shoes is the updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells to create soft landings with responsive toe-offs; that single midsole change defines the ride and makes the Glycerin 22 feel noticeably smoother than its predecessor. It is also certified as a PDAC A5500 Diabetic shoe and carries the APMA Seal of Acceptance, which matters to buyers seeking dependable comfort and foot health credentials.

Key Features

• Neutral support: Provides a high level of cushioning for road runs and cross training while maintaining a neutral platform for natural foot motion.
• DNA Tuned cushion: Larger heel cells yield plush landings while smaller forefoot cells deliver more energetic toe-offs for a balanced stride.
• Accommodating fit: The double jacquard knit upper stretches to reduce pressure points and increases breathability during longer sessions.
• Smooth transitions: A broad platform and tuned heel and forefoot combine to stabilize the foot and smooth heel-to-toe movement.
• Health-oriented certifications: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance for promoting foot health.

Who It's For

The Glycerin 22 is aimed at women who prioritize maximum cushioning and a plush ride for road running, long walks, gym sessions, or everyday wear. Runners who enjoyed the Glycerin 21 will find familiar comfort in an updated midsole that emphasizes seamless transitions and added responsiveness.

Those who need pronounced motion control or heavy pronation correction should look instead at stability models such as the Brooks Glycerin GTS 22 or other stability shoes; the Glycerin 22 intentionally delivers neutral support and a soft, cushioned platform rather than rigid corrective elements.

Pros & Cons

Pros

• Exceptional cushioning and comfortable padded heel praised by customers for long wear.
• Accommodating toe box and flexible knit upper that reduce hotspots and improve fit.
• Certified for diabetic use and APMA-accepted, offering peace of mind for foot health concerns.
• Smooth, stable transitions thanks to a broad platform and tuned midsole geometry.

Cons

• Some buyers feel the price is high compared with the value, so price-sensitive shoppers may balk.
• Neutral support may not suit runners who require extra stability or strong pronation control.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for runners and active women who want maximum cushioning, a plush heel strike, and smoother toe-offs without stability hardware. Its health-focused certifications and comfortable knit upper make it a sensible buy for those who value long-run comfort and foot health, though shoppers seeking corrective support or a budget option should consider alternatives.

Frequently Asked Questions

Are these shoes good for long road runs?
Yes. The high level of cushioning and smooth transitions make them well suited to longer road runs and extended wear.

Do they provide arch support for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing extra support should choose a stability model such as the Glycerin GTS 22.

Are they safe for diabetic feet?
They are certified PDAC A5500 and carry the APMA Seal, indicating they meet standards for diabetic and foot-health considerations.