Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 49YX)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and walkers who want maximum soft cushioning without extra stability hardware. The biggest reason to buy is the DNA Tuned midsole, which blends larger heel cells with smaller forefoot cells to deliver plush landings and energetic toe-offs while maintaining a broad, stable platform. It is a neutral road running shoe with an accommodating double jacquard knit upper and certification as a PDAC A5500 diabetic shoe plus the APMA Seal of Acceptance, making comfort and foot health the central selling points.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide soft, luxurious landings while smaller forefoot cells support responsive toe-offs for smoother transitions.
• Neutral Support: Designed for neutral runners seeking the maximum amount of cushioning for road runs, gym sessions, or long walks without added stability posts.
• Accommodating Fit: The double jacquard knit upper stretches to fit a variety of foot shapes while remaining breathable and durable for regular use.
• Smooth Transitions: A broad platform and tuned heel-to-forefoot geometry help stabilize the foot and promote a steady heel-to-toe roll.
• Health Certifications: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, supporting foot health concerns.

Who It's For

The Glycerin 22 is ideal for road runners, frequent walkers, and anyone who values cushioning above a firm, race-oriented ride. It suits people who spend long periods on their feet, need extra protection for knees and hips, or prefer a roomy toe box and soft midsole feel.

Runners who need pronounced stability or motion control should look at support-specific models such as those designed with guide rails; also, those who prefer a very firm, responsive racing shoe may find the plush Glycerin 22 too soft for tempo work.

Pros & Cons

Pros

• Exceptional cushioning and a soft, squishy sole for long-distance comfort and impact protection.
• Accommodating knit upper that creates a breathable, flexible fit for varied foot shapes.
• Broad platform and tuned geometry deliver smooth, stable heel-to-toe transitions.
• Health-minded certifications including PDAC A5500 and APMA acceptance for added foot-care reassurance.

Cons

• Sizing reports are mixed, with some customers finding the fit smaller than expected, so careful fitting or trying on is advised.
• Very plush cushioning can feel sluggish for runners seeking a firmer, faster daily trainer.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Best Use	Road running, cross training, gym, walking

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, comfort, and foot health certifications. Its DNA Tuned midsole and roomy knit upper make it a comfortable daily trainer for long runs and all-day wear, though those needing firmer responsiveness or added stability should consider alternative models.

Frequently Asked Questions

Do these shoes offer good support for long walks?
Yes; customers note excellent cushioning and knee and hip support that make the Glycerin 22 comfortable for extended walking and standing.

How does the sizing run?
Sizing is reported inconsistently by customers, with some saying they run small, so trying them on or checking retailer fit guidance is recommended.

Are these appropriate for diabetic foot care?
Yes; the shoe is certified PDAC A5500 as a diabetic shoe and carries the APMA Seal of Acceptance, indicating suitability for foot-health concerns.