Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 4TTK)

Our review of the Brooks Womens Glycerin 22 finds it best suited to runners and everyday walkers who prioritize a plush, protective ride. The standout reason to buy is the upgraded DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells for soft landings and lively toe-offs while providing the maximum cushioning in a neutral platform. It also carries certification for diabetic-friendly use and the APMA Seal, making it a strong option for anyone seeking comfort, support, and trusted foot health credentials.

Key Features

• DNA Tuned Cushion: Larger heel cells deliver soft, plush landings while smaller forefoot cells encourage energetic, responsive toe-offs for smoother transitions.
• Neutral Support: Designed as a neutral running shoe, it provides maximal cushioning without added corrective support, ideal for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper stretches to reduce pressure points and improve breathability while maintaining durability.
• Smooth Transitions: A broad platform plus tuned heel and forefoot help stabilize the foot and smooth heel-to-toe motion on road surfaces.
• Approved for Foot Health: Certified as a PDAC A5500 diabetic shoe and honored with the APMA Seal of Acceptance, indicating thoughtful design for foot care needs.

Who It's For

The Glycerin 22 is a good match for neutral runners and people who spend long periods on their feet and need soft, protective cushioning; the roomy toe box and plush sole make it comfortable for long walks, gym sessions, and easy runs. It also appeals to those who value validated foot-health credentials, as it is PDAC certified and APMA accepted.

Runners who need structured stability or gait correction should consider a stability model instead, such as the Glycerin GTS line, since this shoe is explicitly neutral. Also, those who prefer a very firm, minimal feel will find this model too soft and cushioned.

Pros & Cons

Pros

• Exceptional cushioning from the DNA Tuned midsole makes longer distances and standing easier on knees and hips.
• Accommodating knit upper reduces hotspots and improves overall comfort for wide or sensitive feet.
• Broad platform and tuned transition points provide a stable, smooth ride on roads and treadmills.
• PDAC A5500 diabetic certification and APMA Seal offer added reassurance for foot health concerns.

Cons

• Sizing reports are mixed; some customers find the fit smaller than expected, so trying on or sizing up may be necessary.
• The maximal cushioning may feel too soft for runners who prefer a firmer, more responsive ride.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Special Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for neutral runners and daily walkers who want maximum cushioning, a roomy fit, and validated foot-health features. It offers real value for those prioritizing comfort and smooth transitions, though shoppers should verify sizing and avoid it if they need structured stability or a firmer ride.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The plush DNA Tuned midsole and broad platform make them comfortable for extended walking and standing.

Do they offer stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing support should look at stability variants like the Glycerin GTS.

How does sizing run?
Customer feedback is mixed; some report a smaller fit, so consider trying on or ordering a half size up if unsure.