Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 4W81)

In this review the Brooks Womens Glycerin 22 is presented as a top choice for runners and walkers who prioritize maximum cushioning without added corrective support. The bottom line: this shoe delivers plush, balanced rides from heel to toe thanks to the new DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft landings and energetic toe-offs. It also carries certifications for foot health, making it a strong pick for anyone wanting comfort and stability in a neutral running shoe.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells encourage responsive toe-offs for a smoother gait.
• Neutral Support: Designed as a neutral shoe that offers the maximum amount of cushioning without adding corrective motion control, suitable for natural foot strikes.
• Accommodating Fit: The double jacquard knit upper flexes with the foot and offers breathability while giving a roomier toe box for comfort on long walks or runs.
• Smooth Transitions: A broad platform and tuned heel-to-forefoot geometry stabilize the foot and help create steady heel-to-toe transitions.
• Health Certifications: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, indicating attention to foot health and construction standards.

Who It's For

The Glycerin 22 is aimed at women who want plush cushioning for road running, cross training, gym sessions, or long walks where comfort is the priority. It works well for neutral runners who prefer a soft landing and a stable, broad platform rather than corrective or motion-control features. The shoe's certifications also make it appealing to walkers or customers looking for footwear recognized for foot health considerations.

Runners who need added support for overpronation should look at stability versions such as the Glycerin GTS 22. Also, those seeking an ultralight racing shoe or a minimal barefoot feel should consider lighter, lower-cushion alternatives instead.

Pros & Cons

Pros

• Excellent plush cushioning that absorbs impact and remains responsive during toe-off.
• Comfortable, breathable knit upper that adapts to foot shape and provides more room in the toe box.
• Broad, stable platform and tuned geometry that produce smooth heel-to-toe transitions.
• Recognized for foot health with PDAC A5500 certification and the APMA Seal.

Cons

• Some customers report sizing variations, with a number finding the shoe runs small, so careful sizing is recommended.
• The maximal cushioning adds weight compared with lighter trainers, which may not suit fast tempo runs.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Health Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a well engineered neutral running shoe that rewards walkers and runners who value plush cushioning, stable transitions, and an accommodating knit fit. Its foot-health certifications and smooth ride make it a smart buy for everyday training and long-distance comfort, though buyers should verify sizing before ordering.

Frequently Asked Questions

Are these shoes good for long walks?
Yes, customers commonly report comfortable long-distance walking thanks to the maximal cushioning and stable platform.

Do they provide arch support?
They are neutral shoes with generous cushioning; they do not add corrective arch control but many users find they still offer solid support and comfort.

Should I size up or down?
Some buyers report the shoe runs small and others find the toe box roomy; try your usual size but consult the retailer sizing notes or consider a half size up if between sizes.