Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 57GZ)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum plush cushioning with smooth transitions. The standout reason to buy is the upgraded DNA Tuned cushion, which blends larger heel cells with smaller forefoot cells to deliver soft landings and responsive toe-offs. The Glycerin 22 keeps the neutral support of its predecessor while improving fit with a double jacquard knit upper and remains a choice for anyone prioritizing comfort on long road runs or long days on their feet.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot create a plush landing with energized toe-offs for a balanced feel.
• Neutral Support: Provides neutral stability while offering the maximum amount of cushioning, suitable for road running and cross training alike.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce pressure points while maintaining durability across miles.
• Smooth Transitions: A broad platform and tuned heel and forefoot help stabilize the foot and smooth heel-to-toe movement during each stride.
• Medical Endorsements: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 is aimed at neutral runners, walkers, and gym users who prioritize plush cushioning and long-distance comfort. Its high-cushion profile and broad platform benefit people who want shock absorption for long road runs or who spend extended time on their feet.

Runners who prefer minimal or firm shoes, or those needing motion-control or heavy stability features, should look elsewhere-Brooks Glycerin GTS 22 offers similar cushioning with added support for overpronation. Also note that sizing feedback varies, so try a fit check if possible before committing.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact and feels soft underfoot for long distances.
• Accommodating knit upper offers breathable comfort and a roomy toe box for natural toe splay.
• Stable, broad platform and tuned transitions make gait feel smooth from heel to toe.

Cons

• Sizing appears inconsistent across customers, with some reporting a smaller fit than expected, so accurate sizing is important.

Specifications

Model	Glycerin 22
Support type	Neutral
Cushioning	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit for flexibility and breathability
Platform	Broad platform with tuned heel and forefoot
Medical approvals	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong pick for neutral runners and active walkers who want plush, reliable cushioning and smooth transitions. With medical endorsements and an accommodating knit upper, it delivers comfort and support for road running and everyday wear; just double-check sizing before purchase to ensure the best fit.

Frequently Asked Questions

Are these shoes good for long runs?
Yes. The heavy cushioning and stable platform make them comfortable for long road runs and extended walking.

Do they offer support for overpronation?
No. The Glycerin 22 is a neutral shoe; choose the Glycerin GTS 22 for added stability support.

How does the fit run?
Fit can vary-many praise the roomy toe box and accommodating knit upper, but several customers report the sizing runs small, so try before you buy if possible.