Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 5LK7)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a premium neutral trainer built for runners and walkers who want maximal cushioning and smooth transitions. The shoe stands out because of Brooks' DNA Tuned midsole that combines larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, producing a plush but energetic ride. It is also notable for its certified PDAC A5500 diabetic-friendly fit and the APMA Seal of Acceptance, making comfort and foot health central to its design.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel deliver a soft landing while smaller forefoot cells encourage a responsive toe-off for smoother gait transitions.
• Neutral Support: Offers neutral support with maximal cushioning, making it suitable for road running, cross training, or daily wear where comfort is the priority.
• PDAC A5500 Certified: Constructed to meet diabetic shoe standards, providing an accommodating fit and extra consideration for foot health.
• Double Jacquard Knit Upper: The engineered knit upper balances flexibility, durability, and breathability for a comfortable, adaptable fit.
• Stability from Broad Platform: A wide base stabilizes the foot while tuned heel and forefoot geometry smooth heel-to-toe transitions.
• APMA Seal of Acceptance: Independently recognized for promoting good foot health through thoughtful design and cushioning.

Who It's For

The Glycerin 22 is aimed at women who prioritize cushioning and comfort over minimal weight or aggressive responsiveness; long-distance walkers, road runners logging easy to moderate miles, and anyone needing a roomy, protective shoe will appreciate it. The diabetic certification and APMA acceptance also make it a smart choice for buyers concerned about foot health and pressure relief.

Shoppers seeking a highly supportive stability shoe should look at the Glycerin GTS 22 or other models with built-in support guides, and those who want an extremely lightweight, racing-oriented shoe will likely find the Glycerin 22 heavier and more cushioned than ideal.

Pros & Cons

Pros

• Exceptional cushioning and soft heel landings thanks to the DNA Tuned midsole.
• Accommodating, breathable double jacquard knit upper that reduces pressure points.
• Certified PDAC A5500 and APMA Seal of Acceptance for foot-health considerations.
• Broad platform adds stability for smoother transitions and confident road running.

Cons

• Sizing may vary and some customers report they run small, so careful fit checks are recommended.
• Maximal cushioning means the shoe is not the lightest or fastest option for tempo runs or races.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Engineered double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Ideal Uses	Road running, cross training, gym, walking

Our Verdict

The Brooks Womens Glycerin 22 is a top pick for women who want a plush, health-minded everyday trainer that cushions long miles and supports comfortable walking. Its DNA Tuned midsole and broad platform produce smooth, stable transitions, and the diabetic certification adds real value for buyers concerned about foot health. Choose this shoe if maximum cushioning and comfort are your priorities.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers report being able to walk long distances comfortably thanks to the soft cushioning and roomy toe box.

Do they provide support for runners with knee pain?
The plush midsole and stable broad platform offer cushioning and alignment that many users find helpful for knee and hip comfort, though those needing firm corrective support may prefer a stability model.

Should I size up or down?
Opinions vary and some customers find the fit runs small; try the recommended size first and be prepared to size up if you are between sizes or need extra toe-room.