Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 5M6J)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, highly cushioned neutral trainer designed for runners and walkers who prioritize comfort and smooth transitions. The standout reason to consider the Glycerin 22 is its DNA Tuned midsole, which combines larger heel cells and smaller forefoot cells to deliver soft landings and responsive toe-offs while offering the maximum amount of cushioning for neutral support.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells encourage a responsive toe-off for efficient strides.
• Neutral Support: The shoe provides neutral support with the maximum cushioning available in the line, making it suitable for road running and general training.
• Accommodating Fit: A newly engineered double jacquard knit upper offers a flexible, breathable fit that adapts to a variety of foot shapes without feeling restrictive.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot help stabilize the foot and smooth heel-to-toe movement during runs or long walks.
• Medical Approvals: Certified as a PDAC A5500 diabetic shoe and granted the APMA Seal of Acceptance, indicating thoughtful design for foot health.

Who It's For

The Glycerin 22 is best for women who want a soft, protective ride on pavement, gym floors, or long walking days; it suits neutral runners, those recovering from impact-related discomfort, and people who value cushioning and stability in a road running shoe. The broad platform and plush midsole also make it a good choice for cross training where comfort over long durations matters.

Runners who need firm, minimal cushioning or custom-molded stability should look elsewhere, as should those seeking a performance racer or lightweight speed shoe; if you require substantial corrective support, consider models specifically labeled for stability rather than this neutral Glycerin.

Pros & Cons

Pros

• Exceptional cushioning and comfort for long runs and long days on your feet.
• Breathable, flexible double jacquard knit upper that accommodates wider toes and varied foot shapes.
• Smooth, stable transitions from heel to toe thanks to the tuned geometry and broad platform.
• Recognized by PDAC and APMA, offering reassurance for users with foot-health concerns.

Cons

• Sizing can be inconsistent for some customers, with reports that certain fits run small; try before committing if possible.
• The maximum cushioning and broad platform add weight compared with lightweight trainers, which may not suit speed-focused runners.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, a stable platform, and a flexible fit; its DNA Tuned midsole delivers noticeably softer landings with responsive toe-offs. For those prioritizing comfort, foot health endorsements and smooth transitions, it represents good value; skip it if you need a lightweight speed shoe or maximum corrective support.

Frequently Asked Questions

Do these shoes run true to size?
Customers report mixed sizing; some find them true to size while others say they run small, so trying them on or checking retailer return policies is recommended.

Are these suitable for walking long distances?
Yes, the generous cushioning and stable platform make them comfortable for long walks and standing days.

Is this shoe good for people with foot health concerns?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating suitability for some diabetic and foot-health needs.