Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 5Z7D)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and walkers who prioritize long-lasting plush cushioning and smooth transitions. The single biggest reason to consider these shoes is the updated DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs so each run feels cushioned without losing forward momentum. The Glycerin 22 also carries both the APMA Seal of Acceptance and PDAC A5500 diabetic shoe certification, making it a solid option for users who need reliable comfort and supportive construction.

Key Features

• Neutral Support: Delivers maximum cushioning while maintaining a neutral platform suitable for road running, gym sessions, and cross training.
• DNA Tuned Cushion: Larger heel cells provide plush landings and smaller forefoot cells encourage energetic toe-offs for a more efficient stride.
• Accommodating Fit: The double jacquard knit upper offers flexibility and breathability while adapting to different foot shapes for comfort across long distances.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe motion.
• Medical Certifications: Certified PDAC A5500 diabetic shoe and APMA accepted, indicating attention to supportive design and foot health considerations.

Who It's For

The Glycerin 22 is a good match for neutral runners, walkers, and gym-goers who want maximum cushioning and a soft, protective ride. Its roomy toe box and plush sole suit people who log long miles on pavement or spend extended time on their feet and need reliable shock absorption.

Runners who require strong corrective support should consider the Brooks Glycerin GTS 22 or a stability shoe instead, and those who prefer a very firm, race-day feel may find the Glycerin 22 too cushioned for speedwork or tempo sessions.

Pros & Cons

Pros

• Excellent comfort and cushioning with a soft, squishy midsole that protects knees and hips during long walks or runs.
• Accommodating knit upper provides a breathable, flexible fit that adapts to wider feet and bunions.
• Certified for diabetic use and APMA accepted, offering reassurance for foot-health concerns.

Cons

• Sizing opinions vary and some customers report the shoe runs smaller than expected, so trying on or ordering with care is advised.
• Maximum cushioning adds weight compared with minimalist or racing shoes, making it less ideal for speed-focused training.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for anyone who values plush cushioning, smooth heel-to-toe transitions, and an accommodating fit for longer runs or daily wear. Its medical certifications and breathable knit upper add practical value, though shoppers should double-check sizing before buying. Overall it offers good value for runners seeking a cushioned neutral trainer.

Frequently Asked Questions

Do these shoes offer stability for overpronation?
The Glycerin 22 is a neutral shoe; runners needing support for overpronation should look at the Glycerin GTS 22 or a dedicated stability model.

Are these suitable for people with diabetes?
Yes, the shoe is certified PDAC A5500 and carries the APMA Seal of Acceptance, indicating it meets standards often recommended for diabetic foot care.

How does the fit run?
Fit reports vary: many find the toe box roomy and comfortable, but some customers report they run small, so trying on or ordering with a conservative size choice is recommended.