Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 6LDT)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, neutral road running shoe built for runners and walkers who prioritize cushioning and smooth transitions. The standout reason to buy is the updated DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, creating a cushioned yet energetic ride that also earned APMA acceptance and PDAC A5500 diabetic certification.

Key Features

• DNA Tuned Cushion: Dual-size midsole cells give soft, protective heel landings and a more responsive forefoot for livelier toe-offs on the road.
• Neutral Support: Offers maximum cushioning without corrective guidance, making it suitable for neutral runners and everyday gym use.
• Accommodating Fit: The double jacquard knit upper stretches and breathes while holding its shape for a comfortable toe box and reduced pressure points.
• Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and encourage even, stable progress through each stride.
• Medical Certifications: APMA Seal of Acceptance and PDAC A5500 diabetic shoe certification indicate suitability for foot health and extended walking comfort.

Who It's For

Runners and walkers who want plush cushioning for long-distance road miles, recovery runs, or extended time on their feet will appreciate this shoe. It is also a solid choice for gym sessions and cross training when a soft, supportive platform is preferred over a minimal or highly structured trainer.

Those who need firm corrective support for overpronation should look instead at a stability version such as the Glycerin GTS 22, and people who prefer a very lightweight, race-day shoe may find the Glycerin 22 heavier and more cushioned than ideal.

Pros & Cons

Pros

• Exceptional cushioning that protects knees and hips on long walks and runs.
• Breathable, flexible upper that accommodates wider feet and reduces hotspots.
• Smooth heel-to-toe transitions thanks to the broad platform and tuned midsole.
• Medical endorsements that support foot health and diabetic-friendly use.

Cons

• Sizing feedback is mixed; some users find the fit smaller than expected, so trying them on or checking fit guidance is advised.
• Not the best choice for runners seeking strong stability control or a lightweight race shoe.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Intended Use	Road running, cross training, gym, walking
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe

Our Verdict

The Glycerin 22 is a strong choice for anyone who values cushioned comfort and smooth, stable transitions on the road or during long periods on their feet. With its DNA Tuned midsole and accommodating knit upper, it delivers excellent foot protection and durability, making it good value for runners focused on comfort and joint support.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The plush midsole and broad platform provide cushioning and stability for extended walking without excessive fatigue.

Do they offer stability for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing support should consider a stability variant like the Glycerin GTS 22.

How does sizing run?
Customers report mixed sizing; some find them smaller than expected, so trying on or ordering with a return option is recommended.