Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 6M4W)

In this review the Brooks Womens Glycerin 22 Neutral Running Shoe is presented as a top choice for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole that combines larger heel cells for soft landings and smaller forefoot cells for responsive toe-offs, delivering a cushioned yet energetic ride. The shoe is also notable for being a certified PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, which adds confidence for buyers seeking a health-conscious running option.

Key Features

• DNA Tuned Cushion: Dual-size midsole cells give a soft, plush heel strike and a responsive forefoot for smoother transitions between gait phases.
• Neutral Support: Designed as a neutral shoe that provides maximum cushioning without added stability features, ideal for natural foot motion on roads.
• Accommodating Fit: The double jacquard knit upper flexes with the foot for breathability and comfort while maintaining durability for daily use.
• Stable Platform: A broad midsole platform stabilizes the foot and, together with the tuned heel and forefoot, encourages consistent heel-to-toe roll.
• Medical Acceptance: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, supporting suitability for users with diabetic foot concerns.

Who It's For

The Glycerin 22 is best for neutral runners and active walkers who want maximum cushioning for road running, gym sessions, or long walks. It suits people who value a soft, plush sole and an accommodating toe box and who appreciate certified diabetic and podiatric acceptance for added peace of mind.

Those who need structured motion control or corrective support should look at stability-specific models instead, such as shoes with built-in guidance systems. Pick a different shoe if you prefer a very firm, minimalist feel or if you require pronounced pronation control rather than neutral cushioning.

Pros & Cons

Pros

• Exceptional cushioning thanks to the DNA Tuned midsole that balances plush landings with energized toe-offs.
• Comfortable, roomy fit from the double jacquard knit upper that breathes and accommodates foot shape.
• Recognized by PDAC A5500 and the APMA Seal of Acceptance for medical and podiatric suitability.

Cons

• Sizing reports vary; some customers find the fit runs small, so trying on or ordering a half size up may be necessary.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit for flexibility and breathability
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong pick for runners and walkers who want maximum cushioning with a smooth ride and a roomy, comfortable upper. Its medical certifications and plush DNA Tuned midsole make it especially worthwhile for buyers seeking comfort and foot health; just be mindful of sizing and consider trying before committing to a full purchase.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers praise the cushioning and support for long distances and walking without increased foot pain.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing stability should choose a support or guidance model.

How true to size are they?
Sizing reports vary and some find them small; trying on or ordering a half size up is recommended if unsure.