Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 6SN4)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is for runners and walkers who want maximal, plush cushioning with smooth transitions. The shoe stands out because its DNA Tuned midsole blends larger heel cells and smaller forefoot cells to create a soft landing and responsive toe-off, giving long runs and long days on foot a comfortable feel. It also carries PDAC A5500 diabetic certification and the APMA Seal of Acceptance, making it a solid pick for anyone prioritizing foot health alongside cushioning.

Key Features

• DNA Tuned Cushion: A midsole design with larger cells in the heel and smaller cells in the forefoot that delivers plush landings and energetic toe-offs.
• Neutral Support: Provides neutral stability while maximizing cushioning, suitable for road running, the gym, or casual walking.
• Accommodating Fit: The double jacquard knit upper offers flexible stretch and breathability that adapts to a variety of foot shapes.
• Smooth Transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and smooth heel-to-toe motion.
• Certified for Foot Health: PDAC A5500 diabetic certification and the APMA Seal of Acceptance bring extra confidence for users with medical footwear concerns.

Who It's For

The Glycerin 22 is best for neutral runners and active walkers who prioritize cushioning above everything else, including long-distance road runners and gym-goers who spend extended time on their feet. Its roomy toe box and soft sole make it attractive for people seeking comfort and joint support on long walks or low-impact cardio sessions.

Those who need strong motion control, a narrow race shoe, or a very tight performance fit should look elsewhere-for example, runners who prefer a firm, highly responsive ride or a stability model like the Glycerin GTS for added support.

Pros & Cons

Pros

• Generous, plush cushioning that reduces impact on knees and hips for long walks or runs.
• Comfortable, breathable knit upper that adapts to foot shape without feeling restrictive.
• Certified PDAC A5500 and APMA Seal of Acceptance, reassuring for foot health concerns.
• Stable, broad platform that promotes smooth heel-to-toe transitions.

Cons

• Sizing reports vary; some wearers find the fit runs small, so trying before buying or checking return options is advised.
• The focus on maximum cushioning may feel too soft for runners who prefer a firmer, more responsive ride.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit for flexibility and breathability
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Intended Use	Road running, cross training, gym, walking

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who want maximum cushioning and a smooth ride without sacrificing foot health credentials. It is good value for anyone seeking plush support and a breathable, adaptive upper, though those needing firmer responsiveness or exacting race fit may prefer a different model.

Frequently Asked Questions

Are these shoes good for long walks and all-day wear?
The substantial cushioning and roomy toe box make them comfortable for long walks and extended wear, with extra support for knees and hips.

Do these run true to size?
Customer opinions vary and some report a smaller fit, so consider trying them on or checking return options before committing.

Is this shoe suitable for people with diabetic foot concerns?
Yes, it is PDAC A5500 certified and has the APMA Seal of Acceptance, which supports its use for foot health considerations.