Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 766B)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions on the road. The Glycerin 22 stands out because of its DNA Tuned cushion, which blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, delivering a plush yet energetic ride. It is also a certified PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, making it a sensible choice for anyone wanting comfort with medical-minded credentials.

Key Features

• Neutral support: Provides neutral support while delivering the maximum amount of cushioning for road runs and cross training.
• DNA Tuned cushion: Larger midsole cells in the heel create soft landings and smaller forefoot cells encourage a more energetic toe-off.
• Accommodating fit: The double jacquard knit upper flexes to the foot for breathability and a comfortable, durable fit.
• Smooth transitions: The broad platform and tuned heel and forefoot stabilize the foot and smooth heel-to-toe movement.
• Medical certifications: Certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance for foot health-conscious buyers.

Who It's For

The Glycerin 22 is aimed at women who want maximum cushioning without extra stability features, making it ideal for neutral road runners, gym-goers who prefer a soft sole, and those who walk long distances with comfort and joint support. Its certification as a diabetic shoe also makes it appropriate for shoppers seeking approved footwear for sensitive feet.

Runners who need strong motion control or large arch correction should look elsewhere, such as stability-specific models, while athletes seeking a minimalist or racing shoe will find the plush, soft feel of the Glycerin 22 heavier and less responsive for speed-focused workouts.

Pros & Cons

Pros

• Excellent cushioning and comfortable, squishy midsole that reduces impact on knees and hips.
• Accommodating knit upper with good breathability and a roomy toe box for longer wear.
• Stable broad platform and tuned heel/forefoot for smooth transitions.
• Certified PDAC A5500 diabetic shoe and APMA Seal of Acceptance for foot health.

Cons

• Sizing reports vary and some customers find them smaller than expected, so trying on or checking size guidance is advisable.

Specifications

Brand	Brooks
Model	Glycerin 22
Support type	Neutral
Cushion technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Glycerin 22 is a strong pick for women who want plush cushioning, a comfortable breathable fit, and medically recognized footcare credentials; it offers good value for anyone prioritizing comfort over lightweight speed. Try them in-store or verify sizing before committing, especially if you are between sizes.

Frequently Asked Questions

Are these shoes suitable for long-distance walking?
Yes, customers report they can walk long distances comfortably thanks to the soft cushioning and roomy toe box.

Do these provide stability support?
No, the Glycerin 22 is a neutral shoe; choose a stability model like the Glycerin GTS series for added support.

Do they run true to size?
Sizing feedback is mixed and some find them small, so try them on or size up if you are between sizes.