Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 82QK)

In this review the Brooks Womens Glycerin 22 is presented as a premium neutral running shoe for women who prioritize cushioning and smooth transitions. The bottom line: it delivers luxurious, road-ready comfort thanks to Brooks DNA Tuned midsole technology and a broad platform that stabilizes every stride. Certified as a PDAC A5500 diabetic shoe and bearing the APMA Seal of Acceptance, the Glycerin 22 is a strong choice for runners, gym users, and anyone who needs a highly cushioned, accommodating everyday trainer.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide plush landings while smaller forefoot cells promote responsive toe-offs for energetic transitions.
• Neutral Support: Designed as a neutral shoe, it offers maximum cushioning without added motion control, suitable for road running and cross training.
• Accommodating Fit: The double jacquard knit upper stretches where needed for comfort and breathability while maintaining durability in high-wear areas.
• Smooth, Stable Transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement.
• Medical Approvals: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance, indicating foot health considerations were part of the design.

Who It's For

The Glycerin 22 is best for neutral runners who want maximum cushioning on road runs, runners returning to training after injury who need a soft landing, and gym users who prefer a plush trainer for mixed workouts. Its accommodating knit upper also makes it a comfortable option for people who need extra room in the toe box or a padded heel.

Those who need strong stability or corrective support should look at stability-specific models instead, such as the Glycerin GTS line, while racers seeking lightweight, minimal-feel shoes will find the Glycerin 22 heavier and more cushioned than they prefer.

Pros & Cons

Pros

• Exceptional cushioning that keeps long runs comfortable without feeling mushy.
• Accommodating knit upper gives a roomy toe box and good ventilation for daily wear.
• Stable platform and tuned transitions reduce foot fatigue over road miles.
• Certifications (PDAC A5500 and APMA Seal) support foot health credibility.

Cons

• Price can feel high to some buyers despite perceived value for comfort.
• Neutral setup is not suitable for runners who need significant pronation control.

Specifications

Model	Glycerin 22
Intended use	Road running, cross training, gym
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is an excellent pick for runners and active women who prioritize plush cushioning and smooth heel-to-toe transitions. Its accommodating fit and certified foot-health credentials make it good value for those who want comfort and stability on road miles, but shoppers needing corrective support or a lightweight racer should consider other models.

Frequently Asked Questions

Are these shoes good for long road runs?
Yes, the DNA Tuned midsole and broad platform provide plush cushioning and smooth transitions that help on longer road runs.

Do they offer support for diabetic feet?
Yes, the Glycerin 22 is certified as a PDAC A5500 diabetic shoe and also carries the APMA Seal of Acceptance for foot health.

Should I choose these if I overpronate?
No, this is a neutral shoe; runners who need added stability should look at the Glycerin GTS or other stability models.