Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 8627)
Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 8627)
Price subject to change. Tap below for current.
Couldn't load pickup availability
In this review of the Brooks Womens Glycerin 22 neutral running shoe the bottom line is simple: this is a premium cushioned trainer for women who prioritize comfort, smooth transitions and foot protection. Reviewers repeatedly praise the soft, squishy sole and roomy toe box that let you walk long distances or log easy runs with less impact on knees and hips. The shoe's certified diabetic fit and APMA acceptance also make it a compelling choice for anyone needing an accommodating, protective platform without sacrificing a responsive toe-off.
Key Features
- DNA Tuned Cushion: The midsole blends larger heel cells with smaller forefoot cells to deliver plush landings and responsive toe-offs for a balanced ride.
- Neutral Support: Designed as a neutral shoe, it provides maximum cushioning without added motion control for road running, cross training, or gym sessions.
- Accommodating Fit: The double jacquard knit upper stretches for comfort and breathability while retaining durability during long wear.
- Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and smooth the gait cycle from heel strike to push-off.
- Medical Acceptance: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance for foot health benefits.
Who It's For
The Glycerin 22 is best for runners and walkers who want maximal cushioning and a forgiving, roomy fit that reduces pressure on toes and joints. It suits road runners, long-distance walkers, people who cross-train at the gym, and anyone who values a soft, protective midsole on everyday outings.
Those who need strong corrective support or prefer a very firm, minimal shoe should look elsewhere; if you require motion control for severe overpronation, consider stability models rather than this neutral trainer. Also, fit opinions vary, so trying your usual size or checking returns is wise before committing.
Pros & Cons
Pros
- Exceptional cushioning that reduces impact and feels plush underfoot.
- Roomy toe box and accommodating knit upper that improve comfort on long walks.
- Stabilizing broad platform and tuned geometry for smooth heel-to-toe transitions.
- Medical certifications add credibility for foot health and diabetic-friendly wear.
Cons
- Sizing can be inconsistent across customers, with some reporting the shoe runs small, so size carefully.
- The very soft cushioning may feel too plush for runners who prefer a firmer, speed-oriented shoe.
Specifications
| Model | Glycerin 22 |
| Support type | Neutral |
| Midsole tech | DNA Tuned |
| Upper | Double jacquard knit |
| Medical | PDAC A5500 certified; APMA Seal of Acceptance |
| Predecessor | Glycerin 21 |
Our Verdict
The Brooks Womens Glycerin 22 is recommended for runners and walkers who want luxurious cushioning, a roomy fit and a smooth, stable ride; its DNA Tuned midsole and medical certifications make it a strong value for anyone prioritizing comfort and foot health. Size carefully if you are between sizes or prefer a snug fit.
Frequently Asked Questions
Are these shoes good for long walks?
Yes. Customers report comfortable long-distance walking with reduced knee and hip discomfort thanks to the plush cushioning and roomy toe box.
Do they offer stability for overpronation?
No. The Glycerin 22 is a neutral support shoe; those needing added support should consider stability variants instead.
Is the fit true to size?
Fit varies by customer report; some find them small, so try your normal size and check return options if unsure.
Editor's Take
The Glycerin 22 offers luxurious cushioning, a roomy fit and smooth transitions, making it an excellent choice for runners and walkers who prioritize comfort and foot health; size carefully.

Recently viewed
Recently viewed products will appear here as customers browse the store.