Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 9C12)

Our review of the Brooks Womens Glycerin 22 finds it best suited to runners and walkers who want maximum softness underfoot without added stability devices. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells for a plush landing with smaller forefoot cells for a responsive toe-off, delivering a smooth, cushioned ride. It also carries the APMA Seal of Acceptance and a PDAC A5500 diabetic certification, which reinforces its focus on comfort and an accommodating fit for longer wear.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel give soft landings while smaller forefoot cells help push off with energy for smoother transitions.
• Neutral Support: Provides neutral support with maximum cushioning, making it suitable for road running, gym sessions, and long walks.
• Double Jacquard Knit Upper: A newly engineered knit delivers a flexible, breathable, and durable fit that accommodates a range of foot shapes.
• Broad Platform: The wide base stabilizes the foot through heel-to-toe movement for a steady ride without heavy guidance.
• Certified Comfort: PDAC A5500 diabetic shoe certification and the APMA Seal highlight its design for foot health and long-wear comfort.

Who It's For

The Glycerin 22 is ideal for women who prioritize cushioning over aggressive stability - road runners who log steady miles, gym-goers who want soft support for cross training, or anyone seeking a daily trainer that reduces impact on knees and hips. Its roomy toe box and plush sole suit walkers and people who spend hours on their feet.

Shoppers who need strong corrective support or who prefer a very snug, performance race fit should look elsewhere or consider a stability variant like the Glycerin GTS 22. Also, prospective buyers should verify sizing carefully, as customer feedback shows inconsistencies in how these run.

Pros & Cons

Pros

• Exceptional plush cushioning that helps reduce joint strain on long walks and runs.
• Accommodating knit upper and roomy toe box for comfortable all-day wear.
• APMA and PDAC certifications indicate attention to foot health and diabetic-friendly design.
• Broad platform and tuned heel improve stability and create smooth transitions.

Cons

• Sizing reports vary, with some customers finding them smaller than expected, so fit can be unpredictable.
• As a maximal cushion neutral shoe, it may feel too soft for runners who prefer a firmer, race-oriented ride.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral support
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for those who prioritize plush comfort and a smooth ride over performance firmness; its cushioned DNA Tuned midsole and accommodating knit upper make it worth considering for daily training, long walks, and anyone needing added foot comfort. Confirm sizing before you buy, but for cushioning and support that eases joint stress, it represents good value.

Frequently Asked Questions

Are these shoes good for people with diabetic foot concerns?
Yes, the Glycerin 22 is certified PDAC A5500 and has the APMA Seal, indicating it meets criteria for diabetic-friendly and foot-health focused design.

Do they provide stability for overpronation?
No, this model offers neutral support; customers needing additional stability should consider the Glycerin GTS 22 or other stability options.

How do they fit?
The knit upper is accommodating and the toe box is roomy, but customer reports on sizing vary, so trying them on or checking the retailer's fit guidance is recommended.