Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 9WNV)
Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style 9WNV)
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In this review the Brooks Womens Glycerin 22 stands out as a top choice for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is its DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells to deliver soft landings and responsive toe-offs while preserving a broad, stable platform. The shoe is also notable for being a certified PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, which reinforces its focus on comfort and foot health.
Key Features
- DNA Tuned Cushion: Larger midsole cells in the heel and smaller forefoot cells provide a blend of soft landings and energetic toe-offs for road running and long walks.
- Neutral Support: The Glycerin 22 offers maximum cushioning with neutral support, suitable for runners who do not require motion control.
- Accommodating Fit: The double jacquard knit upper delivers flexibility and breathability while accommodating a range of foot shapes and a roomy toe box.
- Smooth Transitions: A broad platform combined with a tuned heel and forefoot smooths heel-to-toe movement and adds sidewalk and road stability.
- Foot Health Certifications: Certified PDAC A5500 and APMA Seal of Acceptance indicate suitability for users needing extra cushioning and protective features.
Who It's For
The Glycerin 22 is best for women who want a highly cushioned, neutral road shoe for daily runs, long walk days, gym sessions, or cross training where comfort is the priority. Runners with knee or hip sensitivity or those who prefer a soft, squishy ride will appreciate the plush midsole and stable platform.
Shoppers who need structured support for overpronation should look at stability alternatives rather than this neutral model, and those seeking a very snug, narrow fit may find the accommodating knit and roomier toe box less precise.
Pros & Cons
Pros
- Excellent cushioning and comfort for long distances and everyday wear.
- Accommodating knit upper provides breathability and a roomy toe box for better comfort.
- Certified PDAC A5500 and APMA acceptance support foot health needs.
- Stable, broad platform aids smooth heel-to-toe transitions.
Cons
- Sizing reports vary, with some customers finding them smaller than expected, so trying before committing is advised.
- Neutral design may not suit those who require added stability or motion control.
Specifications
| Model | Glycerin 22 |
| Support | Neutral |
| Midsole Technology | DNA Tuned with dual-size cells |
| Upper | Double jacquard knit, breathable and flexible |
| Certifications | PDAC A5500 diabetic shoe, APMA Seal of Acceptance |
| Predecessor | Glycerin 21 |
Our Verdict
The Brooks Womens Glycerin 22 is an excellent choice for women seeking maximum cushioning and a comfortable, stable ride for road running, long walks, and cross training. Its DNA Tuned midsole and accommodating knit upper make it a good value for those prioritizing comfort and foot health, while shoppers needing firm stability or precise narrow fits should consider other options.
Frequently Asked Questions
Do these run true to size?
Customer reports vary; some find a snug fit so trying one size up is recommended if between sizes.
Are these suitable for long runs?
Yes, the plush cushioning and smooth transitions make them well suited for long road runs and extended walking.
Is this shoe good for people with foot health needs?
Yes, the PDAC A5500 certification and APMA Seal indicate suitability for users who need extra cushioning and protective features.
Editor's Take
The Glycerin 22 delivers plush, neutral cushioning and smooth transitions thanks to its DNA Tuned midsole, making it a strong pick for women who prioritize comfort and foot health on road runs and long walks.

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