Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style B48J)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and gym-goers who want maximum cushioning without added corrective support; the single biggest reason to buy is the updated DNA Tuned cushion that blends larger heel cells and smaller forefoot cells for soft landings and responsive toe-offs. The shoe is presented as a neutral trainer with a broad platform for stable transitions and an accommodating double jacquard knit upper that balances breathability and a flexible fit, making it a solid option for long road miles, cross training, or daily wear.

Key Features

• Neutral support: Delivers the maximum amount of cushioning while maintaining a neutral ride ideal for road running and gym sessions.
• DNA Tuned cushion: Larger midsole cells in the heel create plush landings while smaller forefoot cells provide a more energetic toe-off.
• Accommodating upper: The double jacquard knit construction stretches where needed to reduce pressure points and improve breathability.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry stabilize the foot and promote steady heel-to-toe movement.
• Medical endorsements: Certified as a PDAC A5500 Diabetic shoe and granted the APMA Seal of Acceptance, suggesting attention to therapeutic fit and foot health.

Who It's For

The Glycerin 22 suits neutral runners who prioritize plush cushioning and a soft ride over corrective support, and it works well for those who mix road miles with gym workouts or need a roomy toe box and padded heel for comfort. The shoe's diabetic certification and APMA acceptance also make it a sensible option for buyers seeking a shoe that supports foot health.

Runners who require firm stability or heavy motion control should look at support models instead, such as the Glycerin GTS line, while those wanting an ultra-light race flat may prefer a less cushioned option for speedwork.

Pros & Cons

Pros

• Exceptional cushioning from the DNA Tuned midsole that softens impact without feeling sluggish.
• Accommodating knit upper provides a flexible, breathable fit with room in the toes.
• Broad platform and tuned transitions give stable, smooth heel-to-toe movement.
• Certified PDAC A5500 and APMA accepted, which supports foot health considerations.

Cons

• Heavily cushioned ride may feel bulky to runners who prefer a minimal, responsive shoe.
• Some shoppers note mixed value perception, with comfort praised but price seen as high by a few customers.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Use cases	Road running, cross training, gym
Medical endorsements	PDAC A5500 Diabetic certified; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for neutral runners and active users who value plush cushioning, a roomy, breathable fit, and smooth transitions; its medical certifications add confidence for shoppers concerned with foot health. It represents strong value for anyone who prioritizes comfort on road runs and everyday training, though those seeking firmer, lighter, or corrective footwear should consider other models.

Frequently Asked Questions

Are these shoes good for long runs?
Yes. The generous cushioning and stable platform make the Glycerin 22 well suited to long road runs and recovery miles.

Do they provide arch support?
The Glycerin 22 is a neutral shoe with cushioning rather than corrective arch devices; customers report adequate support without aggressive motion control.

How does the fit run?
The double jacquard knit upper offers an accommodating, breathable fit with extra room in the toe box and a padded heel that many find comfortable.