Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style C5L8)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a top choice for women who want maximum cushioning without added stability features. The shoe's standout trait is its updated DNA Tuned cushion, which pairs larger heel cells for soft landings with smaller forefoot cells for lively toe-offs, creating a smooth, energetic ride. It also carries certifications that matter to foot health: a certified PDAC A5500 diabetic shoe and the APMA Seal of Acceptance, which makes it a serious pick for runners or everyday wearers who prioritize comfort and protective design.

Key Features

• Neutral support: Offers the maximum amount of cushioning while maintaining a neutral platform suited to road running and gym use.
• DNA Tuned cushion: Larger heel cells provide plush landings and smaller forefoot cells produce responsive toe-offs for balanced transitions.
• Accommodating fit: The double jacquard knit upper is flexible and breathable while providing a durable, roomy fit especially across the toe box.
• Smooth transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and smooth heel-to-toe movement.
• Health certifications: Certified PDAC A5500 and APMA Seal of Acceptance indicate the shoe meets standards for foot health and diabetic accommodations.

Who It's For

The Glycerin 22 is aimed at runners and active women who want plush cushioning for road miles, cross training sessions, or long periods on their feet. It suits neutral-strike runners and anyone who values a soft ride without corrective support, and the roomy toe and padded heel make it comfortable for longer wear.

Women who need motion control or extra support for severe overpronation should look at stability variants such as the Glycerin GTS 22 or other stability-specific models. Also, runners seeking an ultra-lightweight racing shoe may prefer a more minimal, speed-focused option.

Pros & Cons

Pros

• Exceptional cushioning and comfortable heel landings thanks to the DNA Tuned midsole.
• Roomy, breathable fit from the double jacquard knit upper that accommodates wider toes.
• Certified for foot health with PDAC A5500 and APMA Seal, useful for diabetic and comfort-focused buyers.
• Stable-feeling broad platform smooths transitions without feeling bulky.

Cons

• Not intended as a stability shoe, so runners needing strong corrective support should choose a different model.
• Some customers find the price higher than expected given the category, though many consider the comfort worth it.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is a compelling choice for women seeking plush cushioning and a comfortable, accommodating fit for road running and daily wear. With modern DNA Tuned cushioning, a broad stable platform, and foot-health certifications, it delivers premium comfort and protection, making it good value for buyers prioritizing cushioning and all-day comfort.

Frequently Asked Questions

Are these shoes good for long runs?
Yes. The generous cushioning and stable platform make the Glycerin 22 well suited to long road runs and extended wear.

Do they provide arch support?
The Glycerin 22 is a neutral shoe with comfortable support; it does not provide strong corrective arch support like stability models do.

Are they breathable and roomy?
Yes. The double jacquard knit upper is breathable and designed to offer an accommodating, roomy fit, particularly in the toe box.