Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style C6XD)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a premium, ultra-cushioned neutral trainer for women who prioritize comfort and smooth road transitions. The Glycerin 22 stands out because of its updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells to deliver plush landings and lively toe-offs. It also carries both PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance, making it a strong choice for runners and walkers who need generous cushioning and a roomy, accommodating fit.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning for comfortable road running, cross training, and gym sessions.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot combine for soft landings and responsive toe-offs.
• Accommodating fit: A double jacquard knit upper delivers flexibility and breathability while giving extra room in the toe box and a secure padded heel.
• Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe motion.
• Medical and podiatry approvals: Certified as a PDAC A5500 diabetic shoe and granted the APMA Seal of Acceptance, supporting foot health concerns.

Who It's For

The Glycerin 22 is best for runners, walkers, and gym-goers who want maximum cushioning without added motion-control devices. Women with sensitive feet or those who value a roomy toe box and a padded heel for long days on their feet will appreciate the comfort-focused ride and the supported, stable platform.

It is not aimed at runners who need heavy stability or strong pronation control; those athletes should look at the Glycerin GTS 22 or other stability models. If you prefer a very minimal, low-profile shoe with firm responsiveness, the Glycerin 22's plush feel may feel too soft.

Pros & Cons

Pros

• Excellent, plush cushioning that keeps long road miles comfortable.
• Accommodating double jacquard knit upper gives room in the toes and breathable comfort.
• Certified PDAC A5500 and APMA accepted, offering reassurance for foot health needs.

Cons

• Premium cushioning and features come with a higher price for some buyers.
• Not designed for runners seeking strong motion control or a minimal ride.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is a top pick for women who want maximum cushioning, an accommodating fit, and smooth transitions on the road. Its DNA Tuned midsole and broad platform deliver plush comfort without sacrificing responsiveness, and the PDAC and APMA approvals make it a sensible choice for those with foot health concerns. It is good value for buyers prioritizing comfort over minimalism or heavy stability.

Frequently Asked Questions

Are these shoes good for long road runs?
Yes, the Glycerin 22's plush midsole and stable platform make it well suited to long-distance road running and extended time on your feet.

Do they provide arch support?
They are a neutral shoe with generous cushioning; customers report reasonable arch support without added stability features.

How does the fit compare to previous models?
The double jacquard knit upper offers a more accommodating, flexible fit compared with the predecessor, with noticeable toe-box room and heel padding.