Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style CJX5)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a highly cushioned, neutral road runner that prioritizes comfort and smooth transitions. Built around Brooks' latest DNA Tuned cushioning, the Glycerin 22 blends plush heel landings with responsive toe-offs and a broad platform that stabilizes each stride. The shoe is also certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, which reinforces the shoe's focus on pressure relief and supportive, protective fit for walkers and runners who need extra cushioning.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel create soft, plush landings while smaller forefoot cells encourage energetic toe-offs for smoother gait transitions.
• Neutral Support: Designed for neutral runners, it offers the maximum amount of cushioning without added motion-control elements, suitable for road running and cross training.
• Double Jacquard Knit Upper: The engineered knit delivers a flexible, accommodating fit that balances breathability with durability for longer training sessions.
• Wide, Stable Platform: A broad sole base stabilizes the foot and helps the tuned heel and forefoot produce consistent heel-to-toe transitions.
• Medical Acceptance: Certified PDAC A5500 and APMA-accepted, indicating suitability for users seeking protective, pressure-relieving footwear.

Who It's For

The Glycerin 22 is best for neutral runners and walkers who prioritize cushioning and comfort over aggressive responsiveness. It works well for road running, gym sessions, long walks, and anyone needing a soft, protective sole for daily wear.

Runners who need strong stability or corrective motion control should look elsewhere, such as a GTS model for added support, and those who prefer a very firm, race-day responsive shoe may find the plush feel too soft for tempo or speed-focused training.

Pros & Cons

Pros

• Excellent underfoot cushioning for long distances and impact protection.
• Accommodating knit upper provides a roomy, breathable fit.
• Stable platform and tuned transitions reduce uneven heel-to-toe motion.

Cons

• Sizing feedback is mixed; some wearers report the fit runs small and may need to size up.
• Not intended for runners seeking strong corrective support or minimal, race-oriented shoes.

Specifications

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for runners and walkers who want maximum cushioning, a stable platform, and an accommodating fit. Its medical certifications add confidence for users needing pressure relief, and despite mixed sizing reports, the overall comfort, breathable upper, and smooth transitions make it good value for everyday running and long-distance walking.

Frequently Asked Questions

Do these run true to size?
Customer feedback is mixed; some recommend ordering a half size up if you prefer extra room in the toe box.

Is this shoe good for long-distance walking?
Yes, the plush cushioning and stable platform make it very comfortable for extended walks and long training sessions.

Does it offer motion control?
No, the Glycerin 22 is a neutral shoe; choose the Glycerin GTS for added stability and support.