Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style DF4S)

Our review of the Brooks Womens Glycerin 22 finds it best suited to runners and walkers who prioritize maximal comfort and smooth ride over aggressive responsiveness. The single biggest reason to consider this shoe is its standout DNA Tuned cushion that combines soft landings with a more energetic toe-off, producing a plush yet springy feel underfoot. Certified as a PDAC A5500 Diabetic shoe and carrying the APMA Seal of Acceptance, it also appeals to people seeking an accommodating, health-minded fit without sacrificing the kind of cushioning that makes long miles feel easier.

Key Features

• Neutral support: Provides neutral support while delivering the maximum amount of cushioning for road running and general training.
• DNA Tuned cushion: Larger cells in the heel give soft landings and smaller forefoot cells create a responsive toe-off for balanced transitions.
• Accommodating fit: The double jacquard knit upper flexes and breathes, offering room in the toe box and a comfortable wrap across the midfoot.
• Smooth transitions: A broad platform and tuned heel and forefoot stabilize the foot and smooth heel-to-toe movement.
• Health-oriented design: Certified PDAC A5500 and APMA-accepted, signaling suitability for diabetic foot needs and general podiatric approval.

Who It's For

The Glycerin 22 is ideal for road runners, walkers, gym-goers, and people who spend long periods on their feet and want generous cushioning and a roomy toe box. Its neutral support and plush midsole suit runners who prefer softness and protection over maximal responsiveness, and the APMA acceptance will reassure those with foot health concerns.

Those seeking a highly stable motion-control shoe or firmer, race-oriented responsiveness should look elsewhere; runners who need added medial support may prefer the Glycerin GTS version. Also note some customers report inconsistent sizing, so try before committing if possible.

Pros & Cons

Pros

• Exceptional cushioning and comfort for long walks and runs thanks to the DNA Tuned midsole.
• Breathable, flexible double jacquard knit upper that accommodates wider feet and reduces hotspots.
• Broad platform and tuned geometry create smooth, stable heel-to-toe transitions.
• Certified PDAC A5500 diabetic shoe and APMA Seal of Acceptance for foot health credibility.

Cons

• Sizing can be inconsistent among buyers, with some reporting the shoe runs small.
• Not the best choice for runners seeking maximal support or a very firm, race-ready ride.

Specifications

Brand	Brooks
Model	Glycerin 22
Support	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable
Health certifications	PDAC A5500 certified; APMA Seal of Acceptance

Our Verdict

The Glycerin 22 is a top pick for runners and daily walkers who want plush cushioning, an accommodating fit, and smooth transitions. Its DNA Tuned midsole and supportive platform justify the purchase for anyone prioritizing comfort and foot health, though buyers should confirm sizing before committing.

Frequently Asked Questions

Are these shoes good for long walks?
Yes, customers report excellent comfort and cushioning for long distances, with a roomy toe box that reduces foot fatigue.

Do these provide motion control?
No, the Glycerin 22 is a neutral shoe; choose the Glycerin GTS variant for added support if you need medial control.

How do they fit?
The upper is accommodating and breathable, but sizing has been inconsistent for some buyers, so trying them on or checking return options is recommended.