Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style GY9V)

Our review of the Brooks Womens Glycerin 22 finds it ideal for runners and active women who prioritize soft, consistent cushioning and a roomy, accommodating fit. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells for plush landings with smaller forefoot cells for a responsive toe-off, creating notably smooth transitions from heel to toe. It also carries APMA acceptance and PDAC A5500 diabetic certification, making it a thoughtful option for those who need reliable comfort over long miles or daily wear.

Key Features

• DNA Tuned Cushion: Larger heel cells deliver soft, plush landings while smaller forefoot cells support energetic and responsive toe-offs for smoother stride mechanics.
• Neutral Support: Provides full cushioning without added pronation control, making it suitable for neutral runners who want maximum plushness.
• Accommodating Fit: The double jacquard knit upper flexes with the foot and offers breathability and room in the toe box for comfort during longer runs or cross training.
• Stable Platform: A broad midsole platform stabilizes the foot and, along with the tuned heel and forefoot, promotes steady heel-to-toe transitions.
• Medical Certifications: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 is best for neutral road runners, gym-goers, and walkers who want plush cushioning and a smooth ride without extra stability features. It suits people who value a roomy toe box and a padded heel, including those seeking a shoe with diabetic-friendly credentials and APMA acceptance.

Runners who need firm responsiveness for speed work or heavy motion-control support should look elsewhere; the Glycerin 22 prioritizes maximal cushioning over rigid responsiveness or strong pronation correction. If you want the same aesthetic with added support, consider the Glycerin GTS 22 variant instead.

Pros & Cons

Pros

• Exceptional plush cushioning from the tuned midsole that smooths out each stride.
• Accommodating knit upper that provides roomy comfort and breathability in the toe box.
• Stability from a broad platform and tuned heel supports steady transitions without extra hardware.
• Recognized by APMA and certified PDAC A5500, useful for users concerned with foot health.

Cons

• Maximum cushioning can feel softer than some runners prefer for speedwork or race pacing.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for neutral runners and everyday athletes who want maximal plush cushioning and a roomy, comfortable fit. Its DNA Tuned midsole and stable platform deliver smooth transitions and reliable comfort, making it good value for anyone prioritizing long-run comfort or foot-health certifications over race-day responsiveness.

Frequently Asked Questions

Is the Glycerin 22 good for wide feet?
The knit upper is accommodating and provides a roomier toe box, so it often works well for wider feet, though trying on recommended.

Does this model provide motion control?
No, the Glycerin 22 is a neutral shoe focused on cushioning rather than built-in motion control; choose the Glycerin GTS 22 for added support.

Is it suitable for diabetic users?
Yes, it is certified PDAC A5500 as a diabetic shoe and has the APMA Seal of Acceptance, indicating attention to foot health and comfort.