Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style H5MC)

Our review of the Brooks Womens Glycerin 22 finds a shoe built for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to buy is the updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells for soft landings and responsive toe-offs, making long road miles and all-day wear noticeably gentler on knees and hips. It is also a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, so comfort and foot health are central to its design.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning, suitable for road running, gym sessions, or everyday walking.
• DNA Tuned cushion: Larger midsole cells in the heel give plush landings while smaller forefoot cells encourage a peppy, energetic toe-off.
• Accommodating fit: The double jacquard knit upper stretches to relieve pressure points and improves breathability without sacrificing durability.
• Smooth transitions: A broad platform plus a tuned heel and forefoot smooth heel-to-toe movement for a stable ride.
• Medical acceptance: Certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, supporting foot health concerns.

Who It's For

The Glycerin 22 is best for neutral runners who want maximum cushioning and a soft, protective ride over road surfaces, and for walkers or those with foot health concerns who value certified diabetic footwear and the APMA seal. It also suits gym users and cross trainers who prefer a plush sole rather than a firm, performance-oriented platform.

Those who need motion control or strong pronation support should look at stability models, such as the Glycerin GTS 22 variant, and runners who want a minimal, highly responsive racer shoe may find this model too soft and heavy for tempo work.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact on knees and hips during long walks or runs.
• Accommodating knit upper offers a roomy, breathable fit that many users find comfortable for wide toes.
• Medical certifications add confidence for customers with diabetic foot care needs.

Cons

• Sizing reports vary, with some customers noting the shoe can run small, so trying on or sizing up may be necessary.
• The plush midsole favors comfort over a fast, responsive feel for race-pace training.

Specifications

Brand	Brooks
Model	Glycerin 22
Support	Neutral
Cushioning	DNA Tuned dual-cell midsole
Upper	Double jacquard knit for breathability and flexibility
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for anyone prioritizing plush cushioning and comfortable, stable transitions on the road or in daily wear. Its medical certifications and accommodating fit add real value for those with foot health concerns, though shoppers should verify sizing before purchase when a precise fit is important.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The Glycerin 22's DNA Tuned cushioning and broad platform make it well suited for long-distance walking and extended time on your feet.

Do they provide stability for overpronation?
No. This is a neutral support shoe; customers needing extra pronation control should consider stability models such as the Glycerin GTS 22.

Should I size up or down?
Sizing appears to vary among users, with some reporting a small fit, so trying them on or ordering a half size up is a reasonable precaution.