Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style HXFQ)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is straightforward: this shoe is for runners and active women who want maximum plush cushioning without added stability hardware. The single biggest reason to buy is the updated DNA Tuned cushioned midsole, which balances soft landings with a responsive toe-off for smooth transitions. It also carries certification as a PDAC A5500 diabetic shoe and the APMA Seal of Acceptance, making it a strong choice for people who need an accommodating, supportive fit without sacrificing comfort or road performance.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning, ideal for runners who do not need corrective support but want plush comfort.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot deliver soft landings and energetic toe-offs for smoother gait cycles.
• Accommodating fit: The double jacquard knit upper stretches where needed while remaining durable and breathable to reduce hot spots on longer runs.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry stabilize the foot and assist heel-to-toe roll.
• Certified diabetic-friendly: PDAC A5500 certification and the APMA Seal of Acceptance signal extra consideration for foot health and comfort.

Who It's For

The Glycerin 22 is best for road runners, gym-goers, and anyone seeking an everyday running shoe with maximal cushioning and an accommodating toe box. Recreational runners who log moderate mileage and value heel cushioning and a plush ride will find it especially appealing.

Those who need strong motion control or built-in overpronation correction should look at stability-specific models rather than this neutral Glycerin. Also, runners who prefer a very firm, minimal feel will find the plush midsole too soft for their tastes.

Pros & Cons

Pros

• Exceptional cushioning and comfortable padded heel that users consistently praise for long wear.
• Accommodating upper with good toe-room and breathability for varied foot shapes.
• Stable, broad platform that helps smooth transitions from heel to toe.
• PDAC A5500 diabetic certification and APMA acceptance for added foot-health confidence.

Cons

• Heavier, plush cushioning may feel bulky to runners who prefer a minimal or highly responsive racing shoe.

Specifications

Model	Glycerin 22 (women)
Support	Neutral
Midsole	DNA Tuned cushioning with dual-size cells
Upper	Double jacquard knit, flexible and breathable
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Successor	Predecessor: Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a reliable choice for women wanting maximum cushioning, an accommodating fit, and smooth ride mechanics. Its certified diabetic-friendly design and plush DNA Tuned midsole make it a strong value for road runners and daily trainers who prioritize comfort over minimalism or aggressive responsiveness.

Frequently Asked Questions

Are these shoes good for wide feet?
Yes; the engineered double jacquard knit upper and roomy toe area provide an accommodating fit for many wider foot shapes.

Do they offer stability for overpronation?
No; the Glycerin 22 is a neutral shoe designed for maximal cushioning rather than motion control; choose a stability model if you need overpronation support.

Is this shoe suitable for diabetic foot care?
Yes; it is PDAC A5500 certified and carries the APMA Seal of Acceptance, which indicates design features that support foot health.