Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style J7L9)

In this review the Brooks Womens Glycerin 22 Neutral Running Shoe is presented as a high-cushion road and gym shoe best for runners and walkers who prioritize comfort and smooth transitions. The single biggest reason to buy is its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver exceptionally soft landings and responsive toe-offs, offering a noticeably plush ride for long walks or daily runs. It also carries the APMA Seal of Acceptance and is a certified PDAC A5500 diabetic shoe, which reinforces its appeal for those needing extra foot care.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot create a balance of soft landings and energetic toe-offs for smoother gait transitions.
• Neutral Support: Designed as a neutral shoe with maximum cushioning, it is suitable for road running, cross training, and long-distance walking without added stability posts.
• Accommodating Fit: The new double jacquard knit upper stretches to fit a variety of foot shapes while maintaining breathability and durability.
• Smooth Transitions: A broad platform plus tuned heel and forefoot promote stable, even heel-to-toe movement during runs and daily wear.
• Medical Approvals: Certified PDAC A5500 diabetic shoe and APMA Seal of Acceptance, which supports foot health and comfort for sensitive feet.

Who It's For

The Glycerin 22 fits runners and walkers who want maximum cushioning without extra support features, and it works well for road runs, treadmill sessions, gym workouts, and long days on your feet. The plush midsole and roomy toe box suit people with mild foot sensitivity or those who value a soft, protective ride.

Those who need firm stability, motion control, or targeted pronation support should look at supportive models rather than this neutral shoe; shoppers who prefer a very snug, narrow fit may also find the accommodating knit upper too spacious.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact and provides comfortable long-distance walking.
• Accommodating knit upper gives a breathable, flexible fit for varied foot shapes.
• Certified PDAC A5500 and APMA acceptance make it a good choice for foot health concerns.
• Stable broad platform and tuned transitions improve gait smoothness.

Cons

• Sizing reports vary and some customers find the shoe runs small, so trying on or checking size guidance is advisable.
• The focus on maximum cushioning may feel too soft for runners who prefer a firmer, more responsive ride.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Tech	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Best Use	Road running, cross training, gym, walking

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and active walkers who want maximum cushioning and a smooth, comfortable ride. Its DNA Tuned midsole and accommodating knit upper deliver plush comfort and reliable transitions, and the medical certifications add real value for foot-sensitive buyers. Those needing firmer responsiveness or extra stability should consider alternatives, but for soft support and everyday comfort this shoe is a solid buy.

Frequently Asked Questions

Does this shoe provide arch support?
The Glycerin 22 is a neutral shoe focused on cushioning rather than built-in arch control; those needing stability should seek supportive variants.

How does sizing run?
Customer reports vary: several users find the shoe roomy in the toe box, while some say it runs small, so checking size guidance or trying on is recommended.

Is this shoe suitable for people with sensitive feet?
Yes; the APMA Seal and PDAC A5500 certification plus the plush midsole make it a good option for people who need extra cushioning and foot protection.