Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style JMQS)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, neutral road shoe built for runners and walkers who prioritize cushioning and smooth transitions. The shoe stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver soft landings and energetic toe-offs, and it carries both APMA acceptance and PDAC A5500 diabetic certification, which underscores the comfort and protective design. Overall it is best for anyone needing maximum cushioning without added stability posts.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller cells in the forefoot produce a combination of plush landings and responsive toe-offs for smoother strides.
• Neutral Support: Provides neutral support with maximum cushioning ideal for road running, gym sessions, and long walks without forcing corrective motion.
• Accommodating Fit: A double jacquard knit upper stretches for a comfortable, breathable fit while remaining durable through regular use.
• Smooth Transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement for more confident pacing.
• Medical Acceptance: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, indicating design features helpful for foot health and comfort.

Who It's For

The Glycerin 22 is aimed at neutral runners and walkers who want maximal cushioning for daily road miles, long walks, or cross-training. Its plush midsole and roomy toe box suit people who need extra shock absorption for knees and hips or who prefer a softer ride for recovery runs and long stands.

Runners who need strong medial support or motion control should look elsewhere, such as styles with added guidance or stability features; if you rely on corrective shoes or require a narrow, tight race fit, this shoe's accommodating knit upper and plush stack may feel too soft or roomy.

Pros & Cons

Pros

• Exceptional cushioning and a soft, squishy sole that many users praise for long-distance comfort.
• Accommodating, breathable knit upper that provides a roomy toe box and comfortable fit for wide feet.
• Stable platform and tuned transition zones that make heel-to-toe movement feel smooth and balanced.
• Recognized by APMA and PDAC A5500 certification, supporting foot health concerns.

Cons

• Sizing reports vary, with some customers finding the shoe runs small, so ordering a half or full size up may be necessary.
• The focus on maximum cushioning may feel too soft or unresponsive for runners who prefer a firm, performance-oriented ride.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size midsole cells
Upper	Double jacquard knit
Use	Road running, cross training, gym, walking
Medical Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe

Our Verdict

The Brooks Glycerin 22 is a strong choice for neutral runners and walkers who want maximum cushioning and a smooth ride; its DNA Tuned midsole and broad platform combine to protect joints while promoting easy transitions. It represents good value for people prioritizing comfort and foot health, though racers and those seeking firmer responsiveness may prefer a different model.

Frequently Asked Questions

Do these run true to size?
Some customers report they run small, so try a half size up if you are between sizes or prefer extra room in the toe box.

Are they good for long runs?
Yes, the plush DNA Tuned cushioning and stable platform make them well suited for long road runs and recovery miles.

Are these shoes suitable for people with foot issues?
The PDAC A5500 diabetic certification and APMA Seal indicate a design that supports foot health, but individuals with specific medical needs should consult a specialist.