Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style PTQB)

Our review of the Brooks Womens Glycerin 22 finds it best suited for runners and walkers who prioritize maximum cushioning and smooth transitions. The single biggest reason to buy is its DNA Tuned cushion, which blends larger heel cells with smaller forefoot cells to deliver soft landings and energetic toe-offs, making long miles and extended walking sessions noticeably easier on knees and hips. The shoe is also certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, which will reassure anyone seeking medically minded comfort.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning to suit road running, cross training, gym use, and walking without forcing corrective motion.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot combine to soften impact and support responsive toe-offs for a smooth gait.
• Accommodating fit: A double jacquard knit upper stretches to fit a variety of foot shapes while offering breathability and durability for daily wear.
• Smooth transitions: The broad platform and tuned heel-to-toe geometry stabilize the foot and smooth the heel-to-toe roll for steady forward motion.
• Medical endorsements: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, which supports its use for sensitive feet.

Who It's For

The Glycerin 22 is ideal for women who want plush cushioning on road runs, long walks, or gym sessions and who appreciate a soft, squishy sole that reduces joint strain. Runners with neutral pronation who value comfort over aggressive responsiveness will find the shoe particularly appealing.

Shoppers who need rigid stability, motion control, or a narrow race shoe should look elsewhere or consider the Glycerin GTS 22 for added support; also, buyers should try on a pair first due to mixed feedback on sizing to avoid surprises in fit.

Pros & Cons

Pros

• Exceptional cushioning that eases impact on knees and hips during long walks or runs.
• Accommodating knit upper gives a comfortable, breathable fit for many foot shapes.
• Stable broad platform and tuned transitions reduce awkward heel-to-toe shifts.
• Certified PDAC A5500 diabetic shoe with APMA Seal of Acceptance for sensitive feet.

Cons

• Sizing feedback is mixed and can run small for some users, so fitting is important.

Specifications

Brand	Brooks
Model	Glycerin 22
Support type	Neutral
Midsole tech	DNA Tuned with varied cell sizes
Upper	Double jacquard knit
Medical	PDAC A5500 certified; APMA Seal
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for anyone who wants maximum cushioning and a smooth, stable ride for road running and extended walking. Its responsive DNA Tuned cushion and accommodating upper make it worth the investment for those prioritizing comfort and joint protection, though shoppers should confirm sizing before buying.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The plush midsole and broad platform provide cushioning and stability that reduce fatigue on long walks.

Do they offer motion control for overpronation?
No. The Glycerin 22 is a neutral shoe; consider the Glycerin GTS 22 for added support if you need motion control.

Are they suitable for sensitive or diabetic feet?
Yes. The shoe is PDAC A5500 certified and has the APMA Seal of Acceptance, indicating suitability for sensitive feet.