Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style QM72)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and active women who want maximum plush cushioning without extra corrective support. The standout reason to buy is the latest DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells to deliver soft landings and lively toe-offs. It also carries the APMA Seal of Acceptance and is a certified PDAC A5500 Diabetic shoe, so it reliably serves shoppers who need an accommodating, comfortable fit.

Key Features

• Neutral support: Delivers the maximum amount of cushioning for runners who do not require added stability and prefer a soft, smooth ride on roads and treadmills.
• DNA Tuned cushion: Larger midsole cells in the heel create plush landings while smaller forefoot cells promote a responsive toe-off for natural transitions.
• Accommodating fit: The double jacquard knit upper provides flexibility and breathability while allowing extra room across the toes and forefoot.
• Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement during runs.
• Medical acceptance: Certified as a PDAC A5500 Diabetic shoe and granted the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 is best for neutral road runners, gym-goers, and anyone who prioritizes plush cushioning and a roomy toe box. It suits daily trainers who want a soft ride for easy miles and cross-training, and is especially relevant for customers seeking an accommodating fit with good heel padding and breathability.

Runners who need motion control or pronounced arch corrective features should consider a stability model instead, such as the Glycerin GTS version, because the Glycerin 22 maintains neutral support and focuses on maximum cushioning rather than pronation correction.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that many customers called plush and supportive for everyday runs.
• Roomy toe box and padded heel that reduce pressure points and enhance long-run comfort.
• Breathable, durable double jacquard knit upper that adapts to foot shape without feeling tight.
• Recognized by APMA and certified PDAC A5500, offering confidence for foot health needs.

Cons

• Neutral platform may not suit runners who need added stability or strong arch support.
• Some customers felt the shoe's price point could be high relative to expectations.

Specifications

Model	Glycerin 22
Support	Neutral
Cushion technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit for flexible, breathable fit
Certifications	PDAC A5500 Diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for neutral runners and active women who prioritize plush cushioning, comfort, and an accommodating fit. Its DNA Tuned midsole and broad platform deliver smooth transitions and reliable cushioning, making it a good value for those seeking daily comfort and foot-friendly features.

Frequently Asked Questions

Is the Glycerin 22 good for long runs?
Yes. The plush DNA Tuned cushion and stable broad platform make it comfortable for longer, easy-paced runs.

Will this shoe help with foot health concerns?
It is certified as a PDAC A5500 Diabetic shoe and has the APMA Seal of Acceptance, indicating it is a suitable option when foot comfort and accommodating fit are priorities.

Do these provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing additional support should look at the Glycerin GTS version for added stability.