Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style TJQB)

In this review of the Brooks Womens Glycerin 22 neutral running shoe, the bottom line is simple: this is a cushioning-first daily trainer for women who prioritize a soft, supportive ride and smooth transitions. The Glycerin 22 uses Brooks DNA Tuned midsole technology to combine a luxuriously plush heel with a responsive forefoot, and it comes with both PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance, which underscores its focus on comfort and foot health. For runners, walkers, and cross trainers seeking maximum cushioning in a neutral platform, this shoe stands out.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft landings while smaller forefoot cells help deliver a lively toe-off for balanced energy return.
• Neutral Support: Designed as a neutral shoe, it supplies maximum cushioning without added pronation control, making it versatile for road running and gym sessions.
• Accommodating Fit: The double jacquard knit upper stretches to hug different foot shapes while remaining breathable for long walks or runs.
• Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and promote seamless heel-to-toe roll.
• Medical Acceptance: Certified PDAC A5500 and granted the APMA Seal of Acceptance, which supports its suitability for users needing extra foot care features.

Who It's For

The Glycerin 22 is best for neutral runners, walkers, and anyone who spends hours on their feet and values plush cushioning and foot stability. It works well for road running, long walks, gym workouts, and cross training where a soft, supportive base is preferred.

Shoppers who need firm motion control or a highly structured stability shoe should look elsewhere, such as a GTS (GuideTone support) model. Also, buyers who require a very narrow or extremely precise fit may want to try them on first, since sizing opinions vary among customers.

Pros & Cons

Pros

• Outstanding comfort and cushioning that make long distances and daily wear painless for many users.
• Supportive, broad platform that stabilizes the foot and smooths heel-to-toe transitions.
• Breathable, flexible double jacquard knit upper that accommodates different foot shapes.
• Medical-friendly certifications (PDAC A5500 and APMA) that underscore foot health benefits.

Cons

• Sizing can be inconsistent; some customers report they run small, so trying on or sizing up may be necessary.
• The neutral platform lacks the extra support needed by overpronators seeking stability corrections.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned cushioning with varied cell sizes
Upper	Double jacquard knit, flexible and breathable
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for women seeking the maximum amount of cushioning in a neutral trainer along with medical-minded comfort features. It delivers plush landings, stable transitions, and an accommodating upper, making it worth considering for road runners, walkers, and anyone who prioritizes comfort over rigid support. Those needing targeted stability should consider alternate models.

Frequently Asked Questions

Are these shoes good for long walks and standing all day?
Yes. Customers report the cushioning and broad platform reduce pain during long walks and extended standing shifts.

Do these shoes provide motion control for overpronation?
No. The Glycerin 22 is a neutral shoe; buyers needing added support should look at a stability version such as a GTS model.

How does sizing run?
Sizing opinions vary; some wearers find them smaller than expected, so try them on or consider ordering a half size up if between sizes.