Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style TWLX)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who prioritize cushioning and a smooth ride above all else. The Glycerin 22 delivers plush landings and responsive toe-offs thanks to Brooks' DNA Tuned midsole, and it stands out as a certified PDAC A5500 Diabetic shoe with the APMA Seal of Acceptance. Those who need neutral support, a roomy toe box and a soft, squishy sole will find a lot to like here; it is less suited for people who want a precise race flat or rigid corrective support.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel give soft, plush landings while smaller forefoot cells provide a more energetic toe-off so transitions feel balanced.
• Neutral Support: Designed as a neutral shoe that provides the maximum amount of cushioning without added motion control, making it versatile for road running and gym work.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce hot spots while still holding the foot securely during longer walks or runs.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement for a comfortable gait.
• Medical Approvals: Certified as a PDAC A5500 Diabetic shoe and granted the APMA Seal of Acceptance, indicating attention to foot health and comfort.
• Everyday Versatility: Built for road running but comfortable enough for cross training, the gym, or extended walking without trading away cushioning.

Who It's For

The Glycerin 22 suits women who want maximum cushioning and a forgiving ride: long-distance road runners who favor comfort over a race-oriented feel, walkers who need a soft, supportive sole for long periods on their feet, and anyone with sensitive feet who benefits from the certified diabetic fit and APMA acceptance.

It is not the best choice for runners who need strong corrective support or for those who prefer a stiff, minimal racing shoe. If you require heavy stability or prefer a very snug, narrow race fit, consider other models with support features or a firmer platform.

Pros & Cons

Pros

• Exceptional cushioning and a soft, squishy sole that reduces impact on knees and hips.
• Accommodating, breathable double jacquard knit upper that eases pressure on toes and bunions.
• Certified PDAC A5500 and APMA Seal of Acceptance, reflecting foot health considerations.
• Stable, broad platform that smooths transitions from heel to toe for daily training.

Cons

• Sizing reports vary and some wearers find these run small, so trying on or sizing up may be necessary.
• Not ideal for runners seeking a very firm, performance-oriented racing shoe.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 Diabetic shoe, APMA Seal of Acceptance
Best Use	Road running, cross training, gym, walking

Our Verdict

The Brooks Womens Glycerin 22 is a top choice for women who want plush cushioning, supportive yet neutral geometry, and an accommodating fit that protects sensitive feet. It represents good value for anyone who logs long miles on roads or spends long days on their feet, though shoppers should confirm fit before committing due to mixed sizing feedback.

Frequently Asked Questions

Are these shoes good for long-distance running?
Yes, the Glycerin 22's plush midsole and smooth transitions make it well suited to long road runs and extended walking.

Do they provide stability for overpronation?
No, the Glycerin 22 is a neutral shoe; those needing corrective support should look at stability-specific models.

Should I size up?
Some customers report a small fit, so trying them on or ordering a half size up is reasonable if you are between sizes.