Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style WRGD)

Our review of the Brooks Womens Glycerin 22 finds it best for runners and walkers who prioritize maximum plush cushioning and smooth transitions. The standout is the updated midsole with DNA Tuned technology that combines larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs, making it comfortable for road running, gym sessions, and long walks. The shoe's certification as a PDAC A5500 diabetic shoe and the APMA Seal of Acceptance also mark it as a solid choice for people needing an accommodating, foot-friendly fit.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller cells in the forefoot create a plush heel landing and a responsive toe-off for smoother gait cycles.
• Neutral Support: Provides neutral support while offering the maximum amount of cushioning, suitable for road running and cross training.
• Accommodating Fit: The double jacquard knit upper stretches where needed for a comfortable, breathable fit and a roomy toe box.
• Stable Platform: A broad midsole platform stabilizes the foot and helps produce smooth heel-to-toe transitions on varied surfaces.
• Medical Approvals: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance for foot health benefits.

Who It's For

The Glycerin 22 is ideal for neutral runners and active walkers who want plush cushioning without added motion control, and for people who need an accommodating, health-minded shoe thanks to its PDAC and APMA endorsements. It works well for long road runs, recovery days, gym sessions, and everyday wear where comfort matters most.

Runners who need strong stability or corrective support should consider a GTS or stability model instead, and those seeking a very lightweight, minimal-feel trainer may find the Glycerin 22 heavier and more cushioned than they prefer.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that lets users walk long distances with reduced impact pain.
• Roomy, breathable double jacquard knit upper that accommodates wider toes and orthotic insoles.
• Certified as a PDAC A5500 diabetic shoe and carries the APMA Seal, supporting foot health needs.

Cons

• Some customers report inconsistent sizing, with opinions that the shoe runs small, so careful size selection is advised.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers seeking plush cushioning, a stable broad platform, and an accommodating fit backed by PDAC and APMA approvals. It offers clear value for anyone prioritizing comfort and foot health, though shoppers should confirm sizing before purchase due to variable fit reports.

Frequently Asked Questions

Are these shoes good for long distances?
The Glycerin 22's plush midsole and stabilizing platform make it well suited to long road runs and extended walking sessions.

Do they provide stability for overpronation?
This is a neutral shoe; runners needing corrective support should choose a stability or GTS model instead.

Do they run true to size?
Customer feedback is mixed, with some reporting a small fit, so trying on or checking the retailer's size guidance is recommended.