Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style X3NQ)

Our review of the Brooks Womens Glycerin 22 finds it best suited for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to consider these shoes is the DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells to deliver a soft landing and a responsive toe-off; that engineered feel gives long miles more comfort while the broad platform and tuned heel promote stability. This model also carries the APMA Seal of Acceptance and is a certified PDAC A5500 Diabetic shoe, which makes it appealing for anyone needing an accommodating, medically recognized fit.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller cells in the forefoot create plush landings with energetic toe-offs so runs feel smoother.
• Neutral Support: Offers a neutral platform with the maximum amount of cushioning, ideal for road running, cross training, or gym sessions where softness is preferred.
• Accommodating Fit: The double jacquard knit upper stretches to fit a range of foot shapes while remaining breathable and durable for long use.
• Smooth Transitions: A broad midsole platform with a tuned heel and forefoot helps stabilize the foot and reduces abrupt heel-to-toe shifts.
• Medical Acceptance: Certified PDAC A5500 for diabetic use and granted the APMA Seal of Acceptance, indicating an accommodating, foot-healthy design.

Who It's For

The Glycerin 22 is aimed at women seeking maximum cushioning without added motion control, including road runners who log steady miles, gym users who want soft impact protection, and walkers who need reliable comfort over long distances. It is also a strong choice for people who benefit from medically recognized footwear features thanks to its PDAC and APMA endorsements.

Those who need firm support for severe overpronation should look at more structured models such as a Glycerin GTS option with added stability. Runners after a minimal, fast feel or race-day speedwork will likely prefer a lighter, lower-cushion shoe over the Glycerin 22.

Pros & Cons

Pros

• Exceptional cushioning that protects knees and hips during long walks or easy runs.
• Accommodating knit upper provides a comfortable, breathable fit for varied foot shapes.
• Stable, broad platform and tuned transitions reduce abrupt gait changes for smoother rides.
• Recognized by PDAC and APMA, offering confidence for users with special footcare needs.

Cons

• Sizing reports vary; some customers find the fit smaller than expected, so trying on or checking fit guidance is advised.
• Maximum cushioning adds weight compared with lighter, racing-focused shoes, making it less ideal for speed workouts.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned
Upper	Double jacquard knit
Platform	Broad for stable transitions
Medical Recognition	PDAC A5500 certified; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a smart buy for women who prioritize soft, protective cushioning and a forgiving fit for road miles and long walks. Its DNA Tuned midsole and broad platform deliver smooth, stable transitions, and the PDAC/APMA endorsements add value for customers needing an accommodating shoe. Pick this shoe if comfort and foot health are your top priorities; choose a lighter trainer if you need race-day speed or aggressive responsiveness.

Frequently Asked Questions

Do these run true to size?
Customers report mixed sizing; some find them smaller than expected, so measure your foot and consult the brand size chart before buying.

Are they good for long-distance walking?
Yes, the plush cushioning and stable platform make them well suited for long walks and everyday mileage without sharp impact.

Are these shoes supportive for diabetic feet?
Yes, the shoe is PDAC A5500 certified and has the APMA Seal of Acceptance, indicating an accommodating design appropriate for many diabetic footcare needs.